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CD128/Cxcr2 (CXCR2) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422759

MBS422759 is an antibody targeting Cxcr2. Also known as Goat anti-CD128/Cxcr2 (mouse) Antibody. Reactive in Tested: Mouse; Expected from sequence similarity: Mouse. Host: Goat. More details

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Product Overview

Product Name
CD128/Cxcr2, Polyclonal Antibody
Full Product Name
Goat anti-CD128/Cxcr2 (mouse) Antibody
Product Gene Name
anti-Cxcr2 antibody
Product Synonym Gene Name
CD128
Product Synonym Names
Cxcr2; chemokine (C-X-C motif) receptor 2; CD128; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; IL8RA; Il8rb; mIL-8RH; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; GRO/MGSA receptor; IL-8 receptor alpha chain; IL-8R B; chemokine (C-X-C) receptor 2; high aff; CD128 antibody; CDw128 antibody; chemokine (C-X-C motif) receptor 2 antibody; chemokine (C-X-C) receptor 2 antibody; Cmkar2 antibody; C-X-C chemokine receptor type 2 antibody; CXCR-2 antibody; CXC-R2 antibody; Gpcr16 antibody; GRO/MGSA receptor antibody; high affinity interleukin-8 receptor B antibody; IL-8 receptor alpha chain antibody; IL-8R B antibody; IL8RA antibody; Il8rb antibody; IL-8rb antibody; IL-8Rh antibody; interleukin 8 receptor; beta antibody; interleukin-8 receptor type B antibody; mIL-8RH antibody; Cxcr2 antibody; CD128 / Cxcr2 (mouse)
Immunogen Sequence
EFKVDKFNIE D
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse; Expected from sequence similarity: Mouse
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
CD128 / Cxcr2 peptide (MBS427646) is used for blocking the activity of CD128/Cxcr2 antibody (MBS422759)
Molecular Weight
40,425 Da
Immunogen
Peptide with sequence EFKVDKFNIED-C, from the N Terminus of the protein sequence according to NP_034039.1.
Epitope
N Terminus
Note
Reported isoforms represent identical protein: NP_001548.1, NP_001161770.1. The immunizing peptide represent part of an extracellular domain.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Cxcr2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-Cxcr2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.

Western Blot (WB) of anti-Cxcr2 antibody

(0.3ug/ml) staining of Mouse Colon lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-CXCR2 Polyclonal Antibody – Cat# MBS422759

Other Notes

Small volumes of anti-Cxcr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cxcr2. It may not necessarily be applicable to this product.

NCBI GI #
6753456
NCBI GeneID
12765
NCBI Accession #
NP_034039.1
UniProt Secondary Accession #
Q53X27
UniProt Related Accession #
P35343
GenBank Nucleotide #
NM_009909.3
NCBI Official Full Name
C-X-C chemokine receptor type 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 2
NCBI Official Symbol
Cxcr2
NCBI Official Synonym Symbols
CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH
UniProt Protein Name
C-X-C chemokine receptor type 2
UniProt Synonym Protein Names
GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; CD_antigen: CD182
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
Cxcr2
UniProt Synonym Gene Names
Cmkar2; Gpcr16; Il8rb; CXC-R2; CXCR-2; IL-8R B
UniProt Entry Name
CXCR2_MOUSE
NCBI Protein Information
C-X-C chemokine receptor type 2

UniProt Comments for Cxcr2

IL8RB: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Receptor, cytokine

Cellular Component: cell surface; cytosol; integral to membrane; intracellular; mast cell granule; membrane; plasma membrane

Molecular Function: C-X-C chemokine receptor activity; chemokine receptor activity; G-protein coupled receptor activity; interleukin-8 binding; interleukin-8 receptor activity; protein binding; signal transducer activity

Biological Process: acute inflammatory response to antigenic stimulus; cell surface receptor linked signal transduction; cellular defense response; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of apoptosis; negative regulation of neutrophil apoptosis; neutrophil activation; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of leukocyte chemotaxis; positive regulation of vascular permeability; receptor internalization; signal transduction
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Research Articles on Cxcr2

1. Serum amyloid A1alpha induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cxcr2 antibody

 Reference Product  PubMed Publications
 Cxcl2 antibody  >188 publications with Cxcr2 and Cxcl2
 Cxcl5 antibody  >103 publications with Cxcr2 and Cxcl5
 Cxcl12 antibody  >75 publications with Cxcr2 and Cxcl12
 Cxcl3 antibody  >17 publications with Cxcr2 and Cxcl3
 Ppbp antibody  >13 publications with Cxcr2 and Ppbp

Pathways associated with anti-Cxcr2 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-Cxcr2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >578 publications with Cxcr2 and Inflammation
 Lung Diseases Antibodies  >211 publications with Cxcr2 and Lung Diseases
 Disease Models, Animal Antibodies  >198 publications with Cxcr2 and Disease Models, Animal
 Necrosis Antibodies  >147 publications with Cxcr2 and Necrosis
 Nervous System Diseases Antibodies  >105 publications with Cxcr2 and Nervous System Diseases
 Lung Injury Antibodies  >74 publications with Cxcr2 and Lung Injury
 Sepsis Antibodies  >67 publications with Cxcr2 and Sepsis
 Hypersensitivity Antibodies  >60 publications with Cxcr2 and Hypersensitivity
 Asthma Antibodies  >57 publications with Cxcr2 and Asthma
 Liver Diseases Antibodies  >51 publications with Cxcr2 and Liver Diseases

Organs/Tissues associated with anti-Cxcr2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >148 publications with Cxcr2 and Bone
 Spleen Antibodies  >36 publications with Cxcr2 and Spleen
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