HDAC1 Antibody – Goat Polyclonal

HDAC1: a transcriptional regulator of the histone deacetylase family, subfamily 1. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein type: EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator

Cellular Component: cell soma; chromatin; cytoplasm; cytosol; heterochromatin; histone deacetylase complex; neuron projection; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; perinuclear region of cytoplasm; protein complex; Sin3 complex; transcription factor complex; transcriptional repressor complex

Molecular Function: chromatin binding; deacetylase activity; DNA binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; hydrolase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); NF-kappaB binding; nucleosomal DNA binding; protein binding; protein complex binding; protein deacetylase activity; protein N-terminus binding; transcription activator binding; transcription corepressor activity; transcription factor activity; transcription factor binding

Biological Process: ATP-dependent chromatin remodeling; chromatin modification; circadian regulation of gene expression; circadian rhythm; embryonic digit morphogenesis; endoderm development; epidermal cell differentiation; hippocampus development; histone deacetylation; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of insulin secretion; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron differentiation; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of interleukin-1 production; positive regulation of oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; protein amino acid deacetylation; regulation of transcription, DNA-dependent; response to amphetamine; rhythmic process; transcription, DNA-dependent