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TXNDC5 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422858

MBS422858 is an antibody targeting TXNDC5. Also known as Goat anti-TXNDC5 (aa281-295) Antibody. Reactive in Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TXNDC5, Polyclonal Antibody
Full Product Name
Goat anti-TXNDC5 (aa281-295) Antibody
Product Gene Name
anti-TXNDC5 antibody
Product Synonym Names
Goat Anti-TXNDC5 (aa269-282) Antibody; TXNDC5; thioredoxin domain containing 5 (endoplasmic reticulum); ERP46; EndoPDI; Hcc-2; MGC3178; PDIA15; UNQ364; ER protein 46; endoplasmic reticulum protein ERp46; endoplasmic reticulum resident protein 46; endothelial protein disulphide isomerase; prote; TXNDC5 antibody; thioredoxin domain containing 5 (endoplasmic reticulum) antibody; ERP46 antibody; EndoPDI antibody; Hcc-2 antibody; MGC3178 antibody; PDIA15 antibody; UNQ364 antibody; ER protein 46 antibody; endoplasmic reticulum protein ERp46 antibody; endoplasmic reticulum resident protein 46 antibody; endothelial protein disulphide isomerase antibody; protein disulfide isomerase family A; member 15 antibody; thioredoxin domain-containing protein 5 antibody; thioredoxin related protein antibody; thioredoxin-like protein p46 antibody; TXNDC5 (aa281-295)
Immunogen Sequence
RDLESLREYV ESQLQ
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
TXNDC5 peptide (MBS427714) is used for blocking the activity of TXNDC5 antibody (MBS422858)
Molecular Weight
36,178 Da
OMIM
616412
Immunogen
Peptide with sequence C-RDLESLREYVESQLQ, from the internal region of the protein sequence according to NP_110437.2; NP_001139021.1.
Epitope
Internal region
Note
This antibody is expected to recognize both reported isoforms (NP_110437.2; NP_001139021.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TXNDC5 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-TXNDC5 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 50kDa plus faint 35kDa bands observed in Human Lymph Nodes lysates and 48kDa in Mouse Lymph Node and in Mouse Intestine lysates (calculated MW of 47.6kDa according to Human NP_110437.2, 46.4kDa to Mouse NP_663342.3) and of 36.2kDa according to Human NP_001139021.1. Recommended concentration: 0.1-0.3ug/ml.

Western Blot (WB) of anti-TXNDC5 antibody

(0.1ug/ml) staining of Human Lymph Nodes lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-TXNDC5 Polyclonal Antibody – Cat# MBS422858

Western Blot (WB) of anti-TXNDC5 antibody

(0.1ug/ml) staining of Mouse Lymph Nodes (A) and Mouse Intestine (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-TXNDC5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS422858

Other Notes

Small volumes of anti-TXNDC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TXNDC5. It may not necessarily be applicable to this product.

NCBI GI #
42794771
NCBI GeneID
81567
NCBI Accession #
NP_110437.2
NCBI Related Accession #
NP_001139021.1
UniProt Secondary Accession #
Q5TCQ0; Q8ND33; Q8TCT2; Q9BVH9; B2RDM2
UniProt Related Accession #
Q8NBS9
GenBank Nucleotide #
NM_030810.3
NCBI Official Full Name
thioredoxin domain-containing protein 5 isoform 1
NCBI Official Synonym Full Names
thioredoxin domain containing 5
NCBI Official Symbol
TXNDC5
NCBI Official Synonym Symbols
HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI
UniProt Protein Name
Thioredoxin domain-containing protein 5
UniProt Synonym Protein Names
Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
Protein Family
Thioredoxin domain-containing protein
UniProt Gene Name
TXNDC5
UniProt Synonym Gene Names
TLP46; ER protein 46; ERp46
UniProt Entry Name
TXND5_HUMAN
NCBI Protein Information
thioredoxin domain-containing protein 5

NCBI Summary for TXNDC5

This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for TXNDC5

TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p24.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; lysosomal lumen

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: apoptotic cell clearance; cell redox homeostasis; metabolic process; negative regulation of apoptosis; protein folding
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Research Articles on TXNDC5

1. we defined an important role of TXNDC5 in CRPC and further investigations are needed to screen TXNDC5 antagonists as a novel therapeutic approaches to treat PCa patients with Castration-resistant prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TXNDC5 antibody

 Reference Product  PubMed Publications
 ERO1L antibody  >1 publications with TXNDC5 and ERO1L

Pathways associated with anti-TXNDC5 antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Lysosome Vesicle Biogenesis Pathway antibodies  Lysosome Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-TXNDC5 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >6 publications with TXNDC5 and Immune System Diseases
 Liver Diseases Antibodies  >6 publications with TXNDC5 and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with TXNDC5 and Liver Neoplasms
 Arthritis, Rheumatoid Antibodies  >5 publications with TXNDC5 and Arthritis, Rheumatoid
 Inflammation Antibodies  >3 publications with TXNDC5 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >3 publications with TXNDC5 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >2 publications with TXNDC5 and Kidney Diseases
 Necrosis Antibodies  >2 publications with TXNDC5 and Necrosis
 Atherosclerosis Antibodies  >2 publications with TXNDC5 and Atherosclerosis
 Fatty Liver Antibodies  >1 publications with TXNDC5 and Fatty Liver

Organs/Tissues associated with anti-TXNDC5 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with TXNDC5 and Liver
 Blood Antibodies  >7 publications with TXNDC5 and Blood
 Lung Antibodies  >4 publications with TXNDC5 and Lung
 Kidney Antibodies  >3 publications with TXNDC5 and Kidney
 Prostate Antibodies  >3 publications with TXNDC5 and Prostate
 Stomach Antibodies  >3 publications with TXNDC5 and Stomach
 Bone Antibodies  >2 publications with TXNDC5 and Bone
 Placenta Antibodies  >2 publications with TXNDC5 and Placenta
 Vascular Antibodies  >2 publications with TXNDC5 and Vascular
 Uterus Antibodies  >1 publications with TXNDC5 and Uterus
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