NOX1 Antibody – Goat Polyclonal

This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

NOX1: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.-.-.-; Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Oxidoreductase; Channel, misc.

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: cell junction; early endosome; integral to membrane; NADPH oxidase complex; plasma membrane

Molecular Function: metal ion binding; NADP binding; protein binding; Rac GTPase binding; superoxide-generating NADPH oxidase activity; voltage-gated proton channel activity

Biological Process: angiogenesis; cell migration; extracellular matrix organization and biogenesis; hydrogen peroxide metabolic process; inflammatory response; intracellular pH elevation; NADP metabolic process; positive regulation of cell proliferation; positive regulation of integrin biosynthetic process; positive regulation of JNK cascade; positive regulation of smooth muscle cell proliferation; proton transport; regulation of blood pressure; regulation of systemic arterial blood pressure by renin-angiotensin; respiratory burst; signal transduction; superoxide metabolic process; superoxide release