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ENC1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422916

MBS422916 is an antibody targeting ENC1. Also known as Goat anti-ENC1 Antibody. Reactive in Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ENC1, Polyclonal Antibody
Full Product Name
Goat anti-ENC1 Antibody
Product Gene Name
anti-ENC1 antibody
Product Synonym Names
ENC1; ectodermal-neural cortex 1 (with BTB-like domain); CCL28; ENC-1; FLJ39259; KLHL35; KLHL37; NRPB; PIG10; TP53I10; OTTHUMP00000128235; OTTHUMP00000222054; ectoderm-neural cortex protein 1; ectodermal-neural cortex (with BTB-like domain); kelch-like 35; CCL28 antibody; ectodermal-neural cortex (with BTB-like domain) antibody; ectodermal-neural cortex 1 (with BTB-like domain) antibody; ectoderm-neural cortex protein 1 antibody; ENC1 antibody; ENC-1 antibody; FLJ39259 antibody; kelch-like 35 antibody; kelch-like 37 antibody; kelch-like protein 37 antibody; KLHL35 antibody; KLHL37 antibody; NRPB antibody; nuclear matrix protein NRP/B antibody; nuclear restricted protein; BTB domain-like (brain) antibody; OTTHUMP00000128235 antibody; OTTHUMP00000222054 antibody; p53-induced gene 10 protein antibody; PIG10 antibody; TP53I10 antibody; tumor protein p53 inducible protein 10 antibody
Immunogen Sequence
TSVSHDKLPK VQC
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
ENC1 peptide (MBS427774) is used for blocking the activity of ENC1 antibody (MBS422916)
Molecular Weight
57,854 Da
OMIM
605173
Immunogen
Peptide with sequence TSVSHDKLPKVQC, from the internal region of the protein sequence according to NP_003624.1; NP_001243505.1.
Epitope
Internal region
Note
This antibody is expected to recognize both reported isoforms (NP_003624.1; NP_001243505.1). Reported variants represent identical protein: NP_001243503.1, NP_001243504.1, NP_003624.1.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-ENC1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ENC1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 70kDa band observed in Rat Ovary lysates (calculated MW of 66.1kDa according to Rat NP_001003401.1. Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-ENC1 antibody

(1ug/ml) staining of Rat Ovary lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-ENC1 Polyclonal Antibody – Cat# MBS422916

Other Notes

Small volumes of anti-ENC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ENC1. It may not necessarily be applicable to this product.

NCBI GI #
4505461
NCBI GeneID
8507
NCBI Accession #
NP_003624.1
NCBI Related Accession #
NP_001243505.1
UniProt Secondary Accession #
O75464; Q9UPG9; B4DHJ1; E9PFU0
UniProt Related Accession #
O14682
GenBank Nucleotide #
NM_003633.3
NCBI Official Full Name
ectoderm-neural cortex protein 1 isoform 1
NCBI Official Synonym Full Names
ectodermal-neural cortex 1
NCBI Official Symbol
ENC1
NCBI Official Synonym Symbols
NRPB; CCL28; ENC-1; PIG10; KLHL35; KLHL37; TP53I10
UniProt Protein Name
Ectoderm-neural cortex protein 1
UniProt Synonym Protein Names
Kelch-like protein 37; Nuclear matrix protein NRP/B; p53-induced gene 10 protein
Protein Family
Ectoderm-neural cortex protein
UniProt Gene Name
ENC1
UniProt Synonym Gene Names
KLHL37; NRPB; PIG10; ENC-1
UniProt Entry Name
ENC1_HUMAN
NCBI Protein Information
ectoderm-neural cortex protein 1

NCBI Summary for ENC1

This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
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UniProt Comments for ENC1

ENC1: Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. May be down-regulated in neuroblastoma tumors. Substrate- specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: cell soma; cytoplasm; cytoskeleton; nuclear chromatin; nuclear matrix; nucleolus; nucleoplasm; nucleus

Molecular Function: actin binding; protein binding

Biological Process: multicellular organismal development; negative regulation of translation; nervous system development; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination
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Research Articles on ENC1

1. ENC1 functions as a negative regulator of Nrf2 through suppressing Nrf2 protein translation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ENC1 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with ENC1 and Brain Diseases
 Adenocarcinoma Antibodies  >2 publications with ENC1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >1 publications with ENC1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with ENC1 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >1 publications with ENC1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with ENC1 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with ENC1 and Liver Neoplasms

Organs/Tissues associated with anti-ENC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ENC1 and Brain
 Embryonic Tissue Antibodies  >3 publications with ENC1 and Embryonic Tissue
 Adrenal Gland Antibodies  >2 publications with ENC1 and Adrenal Gland
 Muscle Antibodies  >1 publications with ENC1 and Muscle
 Ovary Antibodies  >1 publications with ENC1 and Ovary
 Liver Antibodies  >1 publications with ENC1 and Liver
 Lung Antibodies  >1 publications with ENC1 and Lung
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