Il-25/Il-17e (IL25) Antibody – Goat Polyclonal

The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

IL25: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. Belongs to the IL-17 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-17E receptor binding

Biological Process: cell surface receptor linked signal transduction; eosinophil differentiation; inflammatory response; inflammatory response to antigenic stimulus; interleukin-13 production; interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; response to fungus; response to nematode