Goat Anti-IL17A Polyclonal Antibody – Cat# MBS423068

(1ug/ml) staining of Human Thymus lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Il-17a (IL17A) Antibody – Goat Polyclonal

Name: IL17A Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS423068
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423068

MBS423068 is an antibody targeting IL17A. Also known as Goat anti-IL-17A Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-17A (IL17A), Polyclonal Antibody

Full Product Name

Goat anti-IL-17A Antibody

Product Gene Name

anti-IL17A antibody

Product Synonym Names

Goat Anti-IL-17A (aa126-137) Antibody; IL17A; interleukin 17A; CTLA8; IL-17; IL-17A; IL17; CTLA-8; OTTHUMP00000016597; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymp; CTLA8 antibody; CTLA-8 antibody; cytotoxic T-lymphocyte-associated antigen 8 antibody; cytotoxic T-lymphocyte-associated protein 8 antibody; cytotoxic T-lymphocyte-associated serine esterase 8 antibody; IL17 antibody; IL-17 antibody; IL17A antibody; IL-17A antibody; interleukin 17 (cytotoxic T-lymp antibody; interleukin 17A antibody; OTTHUMP00000016597 antibody

Immunogen Sequence

TIPRNPGCPN SEDKN

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

17,504 Da

OMIM

603149

Immunogen

Peptide with sequence TIPRNPGCPNSEDKN, from the internal region of the protein sequence according to NP_002181.1.

Epitope

Internal region

Note

This antibody is expected to recognize N terminus of mature protein.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-IL17A antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-IL17A antibody

Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 19kDa band observed in HumanThymus lysates (calculated MW of 17.5kDa according to NP_002181.1). Recommended concentration: 1-3ug/ml.

Other Notes

Small volumes of anti-IL17A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17A. It may not necessarily be applicable to this product.

NCBI GI #

4504651

NCBI GeneID

3605

NCBI Accession #

NP_002181.1

UniProt Secondary Accession #

Q5T2P0

UniProt Related Accession #

Q16552

GenBank Nucleotide #

NM_002190.2

NCBI Official Full Name

interleukin-17A

NCBI Official Synonym Full Names

interleukin 17A

NCBI Official Symbol

IL17A

NCBI Official Synonym Symbols

IL17; CTLA8; IL-17; CTLA-8; IL-17A

UniProt Protein Name

Interleukin-17A

UniProt Synonym Protein Names

Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Protein Family

Interleukin

UniProt Gene Name

IL17A

UniProt Synonym Gene Names

CTLA8; IL17; IL-17; IL-17A; CTLA-8

UniProt Entry Name

IL17_HUMAN

NCBI Protein Information

interleukin-17A

NCBI Summary for IL17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

UniProt Comments for IL17A

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: cytoplasm; external side of plasma membrane; extracellular region; extracellular space

Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein binding

Biological Process: apoptosis; cell death; cell surface receptor linked signal transduction; cell-cell signaling; defense response to fungus; immune response; inflammatory response; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; response to amino acid stimulus

Research Articles on IL17A

1. IL-17A expression in VAT is increased in morbidly obese women, which suggests a link between obesity and innate immunity in low-grade chronic inflammation in morbidly obese women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL17A antibody

Reference Product	PubMed Publications
FOXP3 antibody	>104 publications with IL17A and FOXP3
IL6 antibody	>94 publications with IL17A and IL6
STAT3 antibody	>52 publications with IL17A and STAT3
IL17RA antibody	>38 publications with IL17A and IL17RA
IL22 antibody	>29 publications with IL17A and IL22
TGFB1 antibody	>25 publications with IL17A and TGFB1
STAT1 antibody	>19 publications with IL17A and STAT1
IL17RC antibody	>13 publications with IL17A and IL17RC
TRAF3IP2 antibody	>7 publications with IL17A and TRAF3IP2
NFKB1 antibody	>5 publications with IL17A and NFKB1

Pathways associated with anti-IL17A antibody

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
IL17 Signaling Pathway antibodies	IL17 Signaling Pathway Diagram
IL23-mediated Signaling Events Pathway antibodies	IL23-mediated Signaling Events Pathway Diagram
IL27-mediated Signaling Events Pathway antibodies	IL27-mediated Signaling Events Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Interleukin-17 Signaling Pathway antibodies	Interleukin-17 Signaling Pathway Diagram

Diseases associated with anti-IL17A antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>405 publications with IL17A and Inflammation
Autoimmune Diseases Antibodies	>218 publications with IL17A and Autoimmune Diseases
Disease Models, Animal Antibodies	>173 publications with IL17A and Disease Models, Animal
Necrosis Antibodies	>139 publications with IL17A and Necrosis
Lung Diseases Antibodies	>123 publications with IL17A and Lung Diseases
Hypersensitivity Antibodies	>74 publications with IL17A and Hypersensitivity
Cardiovascular Diseases Antibodies	>62 publications with IL17A and Cardiovascular Diseases
Colitis Antibodies	>55 publications with IL17A and Colitis
Central Nervous System Diseases Antibodies	>54 publications with IL17A and Central Nervous System Diseases
Fibrosis Antibodies	>32 publications with IL17A and Fibrosis

Organs/Tissues associated with anti-IL17A antibody

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>17 publications with IL17A and Mixed