UNC5B Antibody – Goat Polyclonal

UNC5B: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: integral to membrane; lipid raft; membrane; plasma membrane

Molecular Function: netrin receptor activity; protein binding

Biological Process: angiogenesis; anterior/posterior axon guidance; apoptosis; axon guidance; multicellular organismal development; negative regulation of neuron apoptosis; positive regulation of phosphoinositide 3-kinase cascade; signal transduction