Goat Anti-MAT2B Polyclonal Antibody – Cat# MBS423109

(0.3ug/ml) staining of Human Thymus lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

MAT2B Antibody – Goat Polyclonal

Name: MAT2B Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS423109
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423109

MBS423109 is an antibody targeting MAT2B. Also known as Goat anti-MAT2B (isoform 1) Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAT2B, Polyclonal Antibody

Full Product Name

Goat anti-MAT2B (isoform 1) Antibody

Product Gene Name

anti-MAT2B antibody

Product Synonym Names

MAT2B; methionine adenosyltransferase II, beta; MAT-II; MATIIbeta; MGC12237; Nbla02999; SDR23E1; TGR; MAT II beta; OTTHUMP00000160916; OTTHUMP00000160917; OTTHUMP00000224275; OTTHUMP00000224294; beta regulatory subunit of methionine adenosyltransferase; d; beta regulatory subunit of methionine adenosyltransferase antibody; dTDP-4-keto-6-deoxy-D-glucose 4-reductase antibody; MAT II beta antibody; MAT2B antibody; MAT-II antibody; MATIIbeta antibody; methionine adenosyltransferase 2 subunit beta antibody; methionine adenosyltransferase II; beta antibody; MGC12237 antibody; Nbla02999 antibody; OTTHUMP00000160916 antibody; OTTHUMP00000160917 antibody; OTTHUMP00000224275 antibody; OTTHUMP00000224294 antibody; putative protein product of Nbla02999 antibody; SDR23E1 antibody; short chain dehydrogenase/reductase family 23E; member 1 antibody; TGR antibody; MAT2B (isoform 1)

Immunogen Sequence

REKELSIHFV PGS

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

MAT2B peptide (MBS427890) is used for blocking the activity of MAT2B antibody (MBS423109)

Molecular Weight

9,488 Da

OMIM

605527

Immunogen

Peptide with sequence REKELSIHFVPGS-C, from the N Terminus of the protein sequence according to NP_037415.1.

Epitope

N Terminus

Note

This antibody is expected to recognize reported isoform 1 (NP_037415.1) only.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-MAT2B antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-MAT2B antibody

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 37kDa band observed in Human Thymus, Tonsil and Spleen lysates (calculated MW of 37.6kDa according to NP_037415.1). Recommended concentration: 0.3-1ug/ml.

Other Notes

Small volumes of anti-MAT2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAT2B. It may not necessarily be applicable to this product.

NCBI GI #

11034825

NCBI GeneID

27430

NCBI Accession #

NP_037415.1

UniProt Secondary Accession #

Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9UJ54; B2R5Y6

UniProt Related Accession #

Q9NZL9

GenBank Nucleotide #

NM_013283.4

NCBI Official Full Name

methionine adenosyltransferase 2 subunit beta isoform 1

NCBI Official Synonym Full Names

methionine adenosyltransferase 2B

NCBI Official Symbol

MAT2B

NCBI Official Synonym Symbols

TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999

UniProt Protein Name

Methionine adenosyltransferase 2 subunit beta

UniProt Synonym Protein Names

Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase

Protein Family

Methionine adenosyltransferase

UniProt Gene Name

MAT2B

UniProt Synonym Gene Names

TGR; MAT II beta

UniProt Entry Name

MAT2B_HUMAN

NCBI Protein Information

methionine adenosyltransferase 2 subunit beta

NCBI Summary for MAT2B

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

UniProt Comments for MAT2B

MAT2B: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine; Transferase

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cytosol; intracellular; methionine adenosyltransferase complex; mitochondrion; nucleus

Molecular Function: enzyme binding; methionine adenosyltransferase regulator activity; protein binding

Biological Process: methylation; one-carbon compound metabolic process; regulation of catalytic activity; S-adenosylmethionine biosynthetic process

Research Articles on MAT2B

1. Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MAT2B antibody

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Methionine Degradation Pathway antibodies	Methionine Degradation Pathway Diagram
Methionine Degradation Pathway antibodies	Methionine Degradation Pathway Diagram
Methionine Salvage Pathway antibodies	Methionine Salvage Pathway Diagram

Diseases associated with anti-MAT2B antibody

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>8 publications with MAT2B and Liver Diseases
Liver Neoplasms Antibodies	>7 publications with MAT2B and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>5 publications with MAT2B and Carcinoma, Hepatocellular
Liver Cirrhosis Antibodies	>1 publications with MAT2B and Liver Cirrhosis
Lung Diseases Antibodies	>1 publications with MAT2B and Lung Diseases
Neoplasm Metastasis Antibodies	>1 publications with MAT2B and Neoplasm Metastasis
Cardiovascular Diseases Antibodies	>1 publications with MAT2B and Cardiovascular Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with MAT2B and Cell Transformation, Neoplastic
Fatty Liver Antibodies	>1 publications with MAT2B and Fatty Liver

Organs/Tissues associated with anti-MAT2B antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>12 publications with MAT2B and Liver
Muscle Antibodies	>2 publications with MAT2B and Muscle
Blood Antibodies	>1 publications with MAT2B and Blood
Lung Antibodies	>1 publications with MAT2B and Lung