FGF14 Antibody – Goat Polyclonal

FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Cell development/differentiation

Cellular Component: cytosol; extracellular region; intracellular; nucleus

Molecular Function: fibroblast growth factor receptor binding; growth factor activity; heparin binding; receptor binding

Biological Process: adult locomotory behavior; fibroblast growth factor receptor signaling pathway; JNK cascade; nervous system development; neuromuscular process; positive regulation of defense response to virus by host; regulation of postsynaptic membrane potential; regulation of synaptic plasticity; synaptic transmission