Goat Anti-RYK Polyclonal Antibody – Cat# MBS423143

RYK Antibody – Goat Polyclonal

Name: RYK Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS423143
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423143

MBS423143 is an antibody targeting Ryk. Also known as Goat anti-Ryk (mouse) Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$305 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ryk, Polyclonal Antibody

Full Product Name

Goat anti-Ryk (mouse) Antibody

Product Gene Name

anti-Ryk antibody

Product Synonym Names

Ryk; receptor-like tyrosine kinase; AW536699; ERK-3; Vik; NYK-R; growth factor receptor; kinase VIK; met-related kinase; tyrosine-protein kinase RYK; AW536699 antibody; ERK-3 antibody; growth factor receptor antibody; kinase VIK antibody; met-related kinase antibody; NYK-R antibody; receptor-like tyrosine kinase antibody; Ryk antibody; tyrosine-protein kinase RYK antibody; Vik antibody; Ryk (mouse)

Immunogen Sequence

HAKSKVEYKL GFQ

Clonality

Polyclonal

Host

Goat

Species Reactivity

Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

Ryk peptide (MBS427897) is used for blocking the activity of Ryk antibody (MBS423143)

Molecular Weight

66,285 Da

Immunogen

Peptide with sequence C-HAKSKVEYKLGFQ, from the internal region of the protein sequence according to NP_038677.3; NP_001036072.1.

Epitope

Internal region

Note

This antibody is expected to recognize both reported isoforms (NP_038677.3; NP_001036072.1).

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-Ryk antibody

Peptide ELISA (EIA)

Application Notes for anti-Ryk antibody

Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx 85kDa band in Mouse Lung lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 66.3kDa according to NP_038677.3. The 85kDa band was successfully blocked by incubation with the immunizing peptide.

Other Notes

Small volumes of anti-Ryk antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Ryk. It may not necessarily be applicable to this product.

NCBI GI #

110681700

NCBI GeneID

20187

NCBI Accession #

NP_038677.3

NCBI Related Accession #

NP_001036072.1

UniProt Secondary Accession #

Q61890

UniProt Related Accession #

Q01887

GenBank Nucleotide #

NM_013649.3

NCBI Official Full Name

tyrosine-protein kinase RYK isoform 1

NCBI Official Synonym Full Names

receptor-like tyrosine kinase

NCBI Official Symbol

Ryk

NCBI Official Synonym Symbols

Vik; ERK-3; AW536699

UniProt Protein Name

Tyrosine-protein kinase RYK

UniProt Synonym Protein Names

Kinase VIK; Met-related kinase; NYK-R

Protein Family

Tyrosine-protein kinase

UniProt Gene Name

Ryk

UniProt Synonym Gene Names

Mrk

UniProt Entry Name

RYK_MOUSE

NCBI Protein Information

tyrosine-protein kinase RYK

UniProt Comments for Ryk

RYK: a receptor tyrosine kinase of the Ryk family. Associates with, and may modulate the signaling of, EphB2 and EphB3. Expressed in nestin-positive progenitor cells and neurons, some oligodendrocytes, O-2A progenitor cells, and type-2 astrocytes in developing CNS.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.10.1; TK group; Ryk family

Cellular Component: cytoplasm; integral to membrane; membrane; nucleus; plasma membrane

Molecular Function: ATP binding; frizzled binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; Wnt receptor activity; Wnt-protein binding

Biological Process: axon guidance; axonogenesis; corpus callosum development; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neurite development; neuron differentiation; phosphorylation; positive regulation of MAPKKK cascade; protein amino acid phosphorylation; skeletal morphogenesis; Wnt receptor signaling pathway

Research Articles on Ryk

1. Ryk-intracellular domain pathway may impair FOXO protective activity in mutant polyglutamine neurons, suggesting neurons unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in Huntington disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Ryk antibody

Reference Product	PubMed Publications
Wnt5a antibody	>38 publications with Ryk and Wnt5a
Wnt3a antibody	>10 publications with Ryk and Wnt3a
Wnt11 antibody	>8 publications with Ryk and Wnt11
Wnt4 antibody	>7 publications with Ryk and Wnt4
Wnt1 antibody	>7 publications with Ryk and Wnt1
Vangl2 antibody	>6 publications with Ryk and Vangl2
Fzd8 antibody	>4 publications with Ryk and Fzd8
Wnt7a antibody	>2 publications with Ryk and Wnt7a
Dvl1 antibody	>1 publications with Ryk and Dvl1

Pathways associated with anti-Ryk antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram

Diseases associated with anti-Ryk antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>20 publications with Ryk and Nervous System Diseases
Kidney Diseases Antibodies	>6 publications with Ryk and Kidney Diseases
Adenocarcinoma Antibodies	>6 publications with Ryk and Adenocarcinoma
Disease Models, Animal Antibodies	>6 publications with Ryk and Disease Models, Animal
Glioblastoma Antibodies	>5 publications with Ryk and Glioblastoma
Inflammation Antibodies	>5 publications with Ryk and Inflammation
Breast Neoplasms Antibodies	>4 publications with Ryk and Breast Neoplasms
Craniofacial Abnormalities Antibodies	>4 publications with Ryk and Craniofacial Abnormalities
Ovarian Neoplasms Antibodies	>3 publications with Ryk and Ovarian Neoplasms
Proteinuria Antibodies	>3 publications with Ryk and Proteinuria

Organs/Tissues associated with anti-Ryk antibody

Organ/Tissue Name	Pubmed Publications
Other Antibodies	>53 publications with Ryk and Other
Brain Antibodies	>40 publications with Ryk and Brain
Embryonic Tissue Antibodies	>29 publications with Ryk and Embryonic Tissue
Lung Antibodies	>18 publications with Ryk and Lung
Bone Antibodies	>16 publications with Ryk and Bone
Bladder Antibodies	>13 publications with Ryk and Bladder
Muscle Antibodies	>10 publications with Ryk and Muscle
Kidney Antibodies	>10 publications with Ryk and Kidney
Liver Antibodies	>8 publications with Ryk and Liver
Bone Marrow Antibodies	>7 publications with Ryk and Bone Marrow