EEF1A2 Antibody – Goat Polyclonal

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]

EEF1A2: an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Protein type: Translation elongation; Translation

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: cell soma; cytoplasm; eukaryotic translation elongation factor 1 complex; myelin sheath; nucleus

Molecular Function: GTP binding; GTPase activity; protein binding; protein kinase binding; translation elongation factor activity; translation factor activity, nucleic acid binding

Biological Process: positive regulation of apoptosis; response to electrical stimulus; response to inorganic substance; translational elongation

Disease: Epileptic Encephalopathy, Early Infantile, 33; Mental Retardation, Autosomal Dominant 38