Goat Anti-C7 Polyclonal Antibody – Cat# MBS423189

(0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Complement Component 7 (C7) Antibody – Goat Polyclonal

Name: C7 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS423189
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423189

MBS423189 is an antibody targeting C7. Also known as Goat anti-complement component 7 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

complement component 7 (C7), Polyclonal Antibody

Full Product Name

Goat anti-complement component 7 Antibody

Product Gene Name

anti-C7 antibody

Product Synonym Names

C7; complement component 7; complement component C7; C7 antibody; complement component 7 antibody; complement component C7 antibody; Complement component 7; complement component 7

Immunogen Sequence

NELTGQFRNR VINTK

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

complement component 7 peptide (MBS428416) is used for blocking the activity of complement component 7 antibody (MBS423189)

Molecular Weight

93,518 Da

OMIM

217070

Immunogen

Peptide with sequence C-NELTGQFRNRVINTK, from the internal region of the protein sequence according to NP_000578.2.

Epitope

Internal region

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-C7 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-C7 antibody

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 95kDa band observed in Human Liver lysates (calculated MW of 93.5kDa according to NP_000578.2). Recommended concentration: 0.1-0.3ug/ml.

Other Notes

Small volumes of anti-C7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for C7. It may not necessarily be applicable to this product.

NCBI GI #

45580688

NCBI GeneID

730

NCBI Accession #

NP_000578.2

UniProt Secondary Accession #

Q6P3T5; Q92489

UniProt Related Accession #

P10643

GenBank Nucleotide #

NM_000587.2

NCBI Official Full Name

complement component C7

NCBI Official Synonym Full Names

complement component 7

NCBI Official Symbol

UniProt Protein Name

Complement component C7

Protein Family

Complement component

UniProt Gene Name

UniProt Entry Name

CO7_HUMAN

NCBI Protein Information

complement component C7

NCBI Summary for C7

C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]

UniProt Comments for C7

C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: extracellular region; membrane attack complex

Biological Process: complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; regulation of complement activation

Disease: Complement Component 7 Deficiency

Research Articles on C7

1. Complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-C7 antibody

Reference Product	PubMed Publications
CD59 antibody	>28 publications with C7 and CD59
C8G antibody	>9 publications with C7 and C8G
C8A antibody	>7 publications with C7 and C8A
C8B antibody	>6 publications with C7 and C8B

Pathways associated with anti-C7 antibody

Products by Pathway	Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Regulation Of Complement Cascade Pathway antibodies	Regulation Of Complement Cascade Pathway Diagram

Diseases associated with anti-C7 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>278 publications with C7 and Cardiovascular Diseases
Brain Diseases Antibodies	>222 publications with C7 and Brain Diseases
Disease Models, Animal Antibodies	>138 publications with C7 and Disease Models, Animal
Inflammation Antibodies	>135 publications with C7 and Inflammation
Hemorrhage Antibodies	>113 publications with C7 and Hemorrhage
Male Urogenital Diseases Antibodies	>107 publications with C7 and Male Urogenital Diseases
Necrosis Antibodies	>85 publications with C7 and Necrosis
Kidney Diseases Antibodies	>70 publications with C7 and Kidney Diseases
Lung Diseases Antibodies	>66 publications with C7 and Lung Diseases
Nerve Degeneration Antibodies	>54 publications with C7 and Nerve Degeneration

Organs/Tissues associated with anti-C7 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>2361 publications with C7 and Bone
Nerve Antibodies	>1100 publications with C7 and Nerve
Muscle Antibodies	>902 publications with C7 and Muscle
Brain Antibodies	>518 publications with C7 and Brain
Vascular Antibodies	>338 publications with C7 and Vascular
Heart Antibodies	>213 publications with C7 and Heart
Liver Antibodies	>210 publications with C7 and Liver
Kidney Antibodies	>169 publications with C7 and Kidney
Ganglia Antibodies	>136 publications with C7 and Ganglia
Lung Antibodies	>134 publications with C7 and Lung