FSCN1 Antibody – Goat Polyclonal

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Fascin: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Associates with beta-catenin. Ubiquitous. Belongs to the fascin family.

Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: actin cytoskeleton; cell projection membrane; cell-cell adherens junction; cytoplasm; cytoskeleton; filamentous actin; filopodium; growth cone; intercellular junction; lamellipodium; microvillus; podosome; ruffle; stress fiber

Molecular Function: actin binding; actin filament binding; drug binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; anatomical structure morphogenesis; cell migration; cell motility involved in cell locomotion; cell proliferation; establishment of apical/basal cell polarity; intercellular junction assembly; microspike biogenesis; positive regulation of filopodium formation; regulation of actin cytoskeleton organization and biogenesis; regulation of microvillus biogenesis