SOX11 Antibody – Goat Polyclonal

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]

SOX11: Probably important in the developing nervous system. May also have a role in tissue modeling during development.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: cytoplasm; nucleus

Molecular Function: transcription factor activity; translation factor activity, nucleic acid binding

Biological Process: embryonic digestive tract morphogenesis; embryonic skeletal morphogenesis; glial cell development; glial cell proliferation; hard palate development; kidney development; lens morphogenesis in camera-type eye; limb bud formation; negative regulation of lymphocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; neural tube formation; neuron differentiation; oligodendrocyte development; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of hormone secretion; positive regulation of neurogenesis; positive regulation of neuron differentiation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transforming growth factor beta receptor signaling pathway; skeletal development; soft palate development; spinal cord development; sympathetic nervous system development; transcription from RNA polymerase II promoter; translation

Disease: Mental Retardation, Autosomal Dominant 27