GOLPH3 Antibody – Goat Polyclonal

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]

GOLPH3: Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene. Belongs to the GOLPH3/VPS74 family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 5p13.3

Cellular Component: cytosol; endosome; Golgi apparatus; Golgi cisterna; intracellular membrane-bound organelle; mitochondrial intermembrane space; mitochondrion; nucleoplasm; plasma membrane; trans-Golgi network

Molecular Function: enzyme binding; protein binding

Biological Process: cell migration; cell proliferation; gene expression; glycoprotein biosynthetic process; Golgi organization and biogenesis; Golgi to plasma membrane protein transport; Golgi vesicle budding; lamellipodium biogenesis; leukocyte tethering or rolling; negative regulation of apoptosis; positive regulation of protein secretion; positive regulation of TOR signaling pathway; protein retention in Golgi; protein secretion