CD25/IL2RA (IL2RA) Antibody – Goat Polyclonal

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: external side of plasma membrane; integral to membrane; intracellular; plasma membrane

Molecular Function: drug binding; interleukin-2 binding; interleukin-2 receptor activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: activated T cell apoptosis; apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; inflammatory response to antigenic stimulus; MAPKKK cascade; negative regulation of defense response to virus; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of T cell proliferation; Notch signaling pathway; positive regulation of activated T cell proliferation; positive regulation of GTPase activity; positive regulation of T cell differentiation; regulation of T cell homeostatic proliferation; regulation of T cell tolerance induction

Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of