DDX41 Antibody – Goat Polyclonal

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

DDX41: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily.

Protein type: RNA-binding; Helicase; Spliceosome; RNA splicing; EC 3.6.4.13

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: cytosol; endoplasmic reticulum; membrane

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; DNA binding; metal ion binding; protein binding

Biological Process: apoptosis; defense response to virus; multicellular organismal development; nuclear mRNA splicing, via spliceosome; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; regulation of interferon type I production; RNA processing; RNA secondary structure unwinding