CBX7 Antibody – Goat Polyclonal

CBX7: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytoplasm; heterochromatin; nuclear chromatin; nucleoplasm; nucleus; PcG protein complex

Molecular Function: chromatin binding; methylated histone residue binding; protein binding; single-stranded RNA binding

Biological Process: chromatin modification; negative regulation of transcription from RNA polymerase II promoter; response to drug; sebaceous gland development; transcription, DNA-dependent