NUMBL Antibody – Goat Polyclonal

NUMBL: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 19q13.13-q13.2

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: axonogenesis; cytokine and chemokine mediated signaling pathway; lateral ventricle development; nervous system development; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; positive regulation of neurogenesis; protein metabolic process