• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CD3G Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423442

MBS423442 is an antibody targeting CD3G. Also known as Goat anti-CD3G Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD3G, Polyclonal Antibody
Full Product Name
Goat anti-CD3G Antibody
Product Gene Name
anti-CD3G antibody
Product Synonym Names
CD3G; CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; IMD17; T3G; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain; T-cell sur; CD3G antibody; CD3g molecule; gamma (CD3-TCR complex) antibody; CD3-GAMMA antibody; IMD17 antibody; T3G antibody; CD3g antigen; gamma polypeptide (TiT3 complex) antibody; CD3g molecule; epsilon (CD3-TCR complex) antibody; T-cell antigen receptor complex; gamma subunit of T3 antibody; T-cell receptor T3 gamma chain antibody; T-cell surface glycoprotein CD3 gamma chain antibody
Immunogen Sequence
C-QDGVRQSR ASDKQT
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
0.5mg/mL (lot specific)
Preparation and Storage
Aliquot and store at -20°C. Minimize freezing and thawing.
Antibody/Peptide Pairs
CD3G peptide (MBS428189) is used for blocking the activity of CD3G antibody (MBS423442)
OMIM
186740
Immunogen
Peptide with sequence C-QDGVRQSRASDKQT, from the internal region of the protein sequence according to NP_000064.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-CD3G antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-CD3G antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 23kDa band observed in lysates of cell line Jurkat (calculated MW of 20.5kDa according to NP_000064.1). Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-CD3G antibody

MBS423442 (0.3ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-CD3G Polyclonal Antibody – Cat# MBS423442

Other Notes

Small volumes of anti-CD3G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3G. It may not necessarily be applicable to this product.

NCBI GI #
4557429
NCBI GeneID
917
NCBI Accession #
NP_000064.1
UniProt Secondary Accession #
Q2HIZ6
UniProt Related Accession #
P09693
GenBank Nucleotide #
NM_000073.2
NCBI Official Full Name
T-cell surface glycoprotein CD3 gamma chain
NCBI Official Synonym Full Names
CD3g molecule
NCBI Official Symbol
CD3G
NCBI Official Synonym Symbols
T3G; IMD17; CD3-GAMMA
UniProt Protein Name
T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names
T-cell receptor T3 gamma chain; CD_antigen: CD3g
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD3G
UniProt Synonym Gene Names
T3G
UniProt Entry Name
CD3G_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD3 gamma chain

NCBI Summary for CD3G

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CD3G

CD3G: The CD3 complex mediates signal transduction.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: alpha-beta T cell receptor complex; integral to plasma membrane; plasma membrane; T cell receptor complex

Molecular Function: protein heterodimerization activity; receptor signaling complex scaffold activity; T cell receptor binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; establishment and/or maintenance of cell polarity; protein complex assembly; protein transport; regulation of immune response; T cell activation; T cell costimulation; T cell receptor signaling pathway

Disease: Immunodeficiency 17
Show more

Research Articles on CD3G

1. The study identifies an important role of the CD3gamma dileucine motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD3G antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram

Diseases associated with anti-CD3G antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with CD3G and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with CD3G and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with CD3G and Carcinoma, Hepatocellular
 Anemia Antibodies  >1 publications with CD3G and Anemia
 Cell Transformation, Neoplastic Antibodies  >1 publications with CD3G and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with CD3G and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with CD3G and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with CD3G and Neoplasms, Experimental
 Kidney Diseases Antibodies  >1 publications with CD3G and Kidney Diseases

Organs/Tissues associated with anti-CD3G antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with CD3G and Blood
 Thymus Antibodies  >3 publications with CD3G and Thymus
 Testis Antibodies  >1 publications with CD3G and Testis
 Brain Antibodies  >1 publications with CD3G and Brain
 Spleen Antibodies  >1 publications with CD3G and Spleen
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000