CXCR1 Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, cytokine; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: integral to membrane; membrane; plasma membrane

Molecular Function: chemokine receptor activity; G-protein coupled receptor activity; interleukin-8 binding; interleukin-8 receptor activity

Biological Process: cell surface receptor linked signal transduction; chemotaxis; dendritic cell chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; receptor internalization

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To