Goat Anti-LYVE1 Polyclonal Antibody – Cat# MBS423499

(2ug/ml) staining of Human Cerebellum (A) and Liver (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

LYVE1 Antibody – Goat Polyclonal

Name: LYVE1 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS423499
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423499

MBS423499 is an antibody targeting LYVE1. Also known as Goat anti-LYVE1 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LYVE1, Polyclonal Antibody

Full Product Name

Goat anti-LYVE1 Antibody

Product Gene Name

anti-LYVE1 antibody

Product Synonym Names

LYVE1; lymphatic vessel endothelial hyaluronan receptor 1; CRSBP-1; HAR; LYVE-1; XLKD1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain; LYVE1 antibody; lymphatic vessel endothelial hyaluronan receptor 1 antibody; CRSBP-1 antibody; HAR antibody; LYVE-1 antibody; XLKD1 antibody; cell surface retention sequence binding protein-1 antibody; cell surface retention sequence-binding protein 1 antibody; extracellular link domain containing 1 antibody; extracellular link domain-containing 1 antibody; extracellular link domain-containing protein 1 antibody; hyaluronic acid receptor antibody; lymphatic vessel endothelial hyaluronic acid receptor 1 antibody

Immunogen Sequence

STETEPFVEN K

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

LYVE1 peptide (MBS428681) is used for blocking the activity of LYVE1 antibody (MBS423499)

Molecular Weight

35,213 Da

OMIM

605702

Immunogen

Peptide with sequence C-STETEPFVENK, from the internal region of the protein sequence according to NP_006682.2.

Epitope

Internal region

Note

This antibody binds to part of the extracellular domain.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-LYVE1 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-LYVE1 antibody

Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 45kDa band observed in Human Brain (Cerebellum) and 60kDa in Human Liver lysates (calculated MW of 35.2kDa according to NP_006682.2). The observed molecular weights correspond to the different glycosylated forms. Recommended concentration: 1-3ug/ml.

Other Notes

Small volumes of anti-LYVE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LYVE1. It may not necessarily be applicable to this product.

NCBI GI #

40549451

NCBI GeneID

10894

NCBI Accession #

NP_006682.2

UniProt Secondary Accession #

Q8TC18; Q9UNF4

UniProt Related Accession #

Q9Y5Y7

GenBank Nucleotide #

NM_006691.3

NCBI Official Full Name

lymphatic vessel endothelial hyaluronic acid receptor 1

NCBI Official Synonym Full Names

lymphatic vessel endothelial hyaluronan receptor 1

NCBI Official Symbol

LYVE1

NCBI Official Synonym Symbols

HAR; XLKD1; LYVE-1; CRSBP-1

UniProt Protein Name

Lymphatic vessel endothelial hyaluronic acid receptor 1

UniProt Synonym Protein Names

Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor

Protein Family

Lymphatic vessel endothelial hyaluronic acid receptor

UniProt Gene Name

LYVE1

UniProt Synonym Gene Names

CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1

UniProt Entry Name

LYVE1_HUMAN

NCBI Protein Information

lymphatic vessel endothelial hyaluronic acid receptor 1

NCBI Summary for LYVE1

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

UniProt Comments for LYVE1

XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: hyaluronic acid binding; protein binding; receptor activity; transmembrane receptor activity

Biological Process: anatomical structure morphogenesis; cell motility; cell-matrix adhesion; hyaluronan catabolic process; response to wounding; signal transduction; transport

Research Articles on LYVE1

1. Data (including data from studies in knockout mice) suggest LYVE1 mediates adhesion of group A Streptococci (GAS) to lymphatic vesicular endothelium via capsular hyaluronan; this appears to be critical factor for lymphatic trafficking of GAS in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LYVE1 antibody

Reference Product	PubMed Publications
CD44 antibody	>24 publications with LYVE1 and CD44
FGF2 antibody	>4 publications with LYVE1 and FGF2
STAB2 antibody	>3 publications with LYVE1 and STAB2
FIGF antibody	>1 publications with LYVE1 and FIGF
ATM antibody	>1 publications with LYVE1 and ATM
HMMR antibody	>1 publications with LYVE1 and HMMR

Pathways associated with anti-LYVE1 antibody

Products by Pathway	Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
Hyaluronan Metabolism Pathway antibodies	Hyaluronan Metabolism Pathway Diagram
Hyaluronan Uptake And Degradation Pathway antibodies	Hyaluronan Uptake And Degradation Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Carbohydrates Pathway antibodies	Metabolism Of Carbohydrates Pathway Diagram

Diseases associated with anti-LYVE1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>26 publications with LYVE1 and Inflammation
Adenocarcinoma Antibodies	>21 publications with LYVE1 and Adenocarcinoma
Breast Neoplasms Antibodies	>19 publications with LYVE1 and Breast Neoplasms
Disease Models, Animal Antibodies	>17 publications with LYVE1 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>14 publications with LYVE1 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>14 publications with LYVE1 and Lung Neoplasms
Lung Diseases Antibodies	>13 publications with LYVE1 and Lung Diseases
Necrosis Antibodies	>12 publications with LYVE1 and Necrosis
Liver Neoplasms Antibodies	>11 publications with LYVE1 and Liver Neoplasms
Edema Antibodies	>11 publications with LYVE1 and Edema

Organs/Tissues associated with anti-LYVE1 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>200 publications with LYVE1 and Vascular
Eye Antibodies	>25 publications with LYVE1 and Eye
Lung Antibodies	>24 publications with LYVE1 and Lung
Muscle Antibodies	>17 publications with LYVE1 and Muscle
Liver Antibodies	>17 publications with LYVE1 and Liver
Embryonic Tissue Antibodies	>16 publications with LYVE1 and Embryonic Tissue
Bone Antibodies	>13 publications with LYVE1 and Bone
Connective Tissue Antibodies	>10 publications with LYVE1 and Connective Tissue
Stomach Antibodies	>10 publications with LYVE1 and Stomach
Heart Antibodies	>9 publications with LYVE1 and Heart