ALDH2 Antibody – Goat Polyclonal

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

ALDH2: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - fatty acid; Amino Acid Metabolism - lysine degradation; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - histidine; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - pyruvate; Secondary Metabolites Metabolism - limonene and pinene degradation; Oxidoreductase; EC 1.2.1.3; Carbohydrate Metabolism - ascorbate and aldarate; Amino Acid Metabolism - tryptophan; Mitochondrial

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: mitochondrial matrix

Molecular Function: aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; electron carrier activity

Biological Process: alcohol metabolic process; carbohydrate metabolic process; ethanol catabolic process; ethanol oxidation

Disease: Alcohol Sensitivity, Acute