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ICOS Ligand/B7-H2 (ICOSLG) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423551

MBS423551 is an antibody targeting ICOSLG. Also known as Goat anti-ICOS ligand/B7-H2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ICOS ligand/B7-H2 (ICOSLG), Polyclonal Antibody
Full Product Name
Goat anti-ICOS ligand/B7-H2 Antibody
Product Gene Name
anti-ICOSLG antibody
Product Synonym Gene Name
B7-H2
Product Synonym Names
ICOSLG; inducible T-cell co-stimulator ligand; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; ICOS ligand; transmembrane protein B7-H2 ICOS ligand; ICOSLG antibody; inducible T-cell co-stimulator ligand antibody; B7-H2 antibody; B7H2 antibody; B7RP-1 antibody; B7RP1 antibody; CD275 antibody; GL50 antibody; ICOS-L antibody; ICOSL antibody; LICOS antibody; B7 homolog 2 antibody; B7 homologue 2 antibody; B7-like protein Gl50 antibody; B7-related protein 1 antibody; ICOS ligand antibody; transmembrane protein B7-H2 ICOS ligand antibody; ICOS ligand; ICOS ligand / B7-H2
Immunogen Sequence
SQTGNDIGER DKIT
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
ICOS ligand / B7-H2 peptide (MBS428705) is used for blocking the activity of ICOS ligand/B7-H2 antibody (MBS423551)
Molecular Weight
20,120 Da
OMIM
605717
Immunogen
Peptide with sequence C-SQTGNDIGERDKIT, from the internal region of the protein sequence according to NP_056074.1; NP_001269979.1; NP_001269980.1; NP_001269981.1.
Epitope
Internal region
Note
This antibody is expected to recognize all reported isoforms (NP_056074.1; NP_001269979.1; NP_001269980.1; NP_001269981.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-ICOSLG antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ICOSLG antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 33kDa band observed in Human Lymph Node lysates (calculated MW of 33.3kDa according to NP_056074.1). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-ICOSLG antibody

(1ug/ml) staining of Human Lymph Node lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-ICOSLG Polyclonal Antibody – Cat# MBS423551

Other Notes

Small volumes of anti-ICOSLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ICOSLG. It may not necessarily be applicable to this product.

NCBI GI #
27477039
NCBI GeneID
23308
NCBI Accession #
NP_056074.1
NCBI Related Accession #
NP_001269979.1; NP_001269980.1; NP_001269981.1
UniProt Secondary Accession #
Q9HD18; Q9NRQ1; A8MUZ1
UniProt Related Accession #
O75144
GenBank Nucleotide #
NM_015259.5
NCBI Official Full Name
ICOS ligand isoform a
NCBI Official Synonym Full Names
inducible T-cell co-stimulator ligand
NCBI Official Symbol
ICOSLG
NCBI Official Synonym Symbols
B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
UniProt Protein Name
ICOS ligand
UniProt Synonym Protein Names
B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275
Protein Family
ICOS ligand
UniProt Gene Name
ICOSLG
UniProt Synonym Gene Names
B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1
UniProt Entry Name
ICOSL_HUMAN
NCBI Protein Information
ICOS ligand

UniProt Comments for ICOSLG

ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: receptor binding

Biological Process: adaptive immune response; B cell activation; defense response; hyperosmotic response; positive regulation of activated T cell proliferation; signal transduction; T cell activation; T cell costimulation
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Research Articles on ICOSLG

1. Loss-of-function mutations in NIK cause impaired ICOSL expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ICOSLG antibody

 Reference Product  PubMed Publications
 ICOS antibody  >67 publications with ICOSLG and ICOS
 CD28 antibody  >28 publications with ICOSLG and CD28
 CTLA4 antibody  >12 publications with ICOSLG and CTLA4
 CXCL12 antibody  >1 publications with ICOSLG and CXCL12

Pathways associated with anti-ICOSLG antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with anti-ICOSLG antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >23 publications with ICOSLG and Necrosis
 Autoimmune Diseases Antibodies  >17 publications with ICOSLG and Autoimmune Diseases
 Inflammation Antibodies  >16 publications with ICOSLG and Inflammation
 Vascular Diseases Antibodies  >9 publications with ICOSLG and Vascular Diseases
 Asthma Antibodies  >9 publications with ICOSLG and Asthma
 Carcinoma Antibodies  >7 publications with ICOSLG and Carcinoma
 Celiac Disease Antibodies  >4 publications with ICOSLG and Celiac Disease
 Colitis, Ulcerative Antibodies  >3 publications with ICOSLG and Colitis, Ulcerative
 Carcinoma, Squamous Cell Antibodies  >2 publications with ICOSLG and Carcinoma, Squamous Cell
 Atherosclerosis Antibodies  >2 publications with ICOSLG and Atherosclerosis

Organs/Tissues associated with anti-ICOSLG antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >86 publications with ICOSLG and Blood
 Lymph Node Antibodies  >8 publications with ICOSLG and Lymph Node
 Lung Antibodies  >6 publications with ICOSLG and Lung
 Brain Antibodies  >6 publications with ICOSLG and Brain
 Liver Antibodies  >5 publications with ICOSLG and Liver
 Skin Antibodies  >5 publications with ICOSLG and Skin
 Kidney Antibodies  >4 publications with ICOSLG and Kidney
 Heart Antibodies  >4 publications with ICOSLG and Heart
 Connective Tissue Antibodies  >3 publications with ICOSLG and Connective Tissue
 Stomach Antibodies  >2 publications with ICOSLG and Stomach
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