• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PON2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423637

MBS423637 is an antibody targeting PON2. Also known as Goat anti-PON2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PON2, Polyclonal Antibody
Full Product Name
Goat anti-PON2 Antibody
Product Gene Name
Product Synonym Names
Goat Anti-PON2 Antibody; PON2; paraoxonase 2; A-esterase 2; aromatic esterase 2; paraoxonase nirs; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2; A-esterase 2 antibody; aromatic esterase 2 antibody; paraoxonase 2 antibody; paraoxonase nirs antibody; serum aryldialkylphosphatase 2 antibody; serum paraoxonase/arylesterase 2 antibody; PON2 antibody
Immunogen Sequence
ERLLALRNRL KAS
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
PON2 peptide (MBS428729) is used for blocking the activity of PON2 antibody (MBS423637)
Molecular Weight
37,996 Da
OMIM
602447
Immunogen
Peptide with sequence C-ERLLALRNRLKAS, from the internal region of the protein sequence according to NP_000296.2; NP_001018171.1.
Epitope
Internal region
Note
This antibody is expected to recognize isoforms 1 and 2 (NP_000296.2; NP_001018171.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-PON2 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-PON2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Immunohistochemistry: In paraffin embedded Human Liver shows membranous staining surrounding the hepatocytes and some background. Recommended concentration, 2-4ug/ml.

Immunohistochemistry (IHC) of anti-PON2 antibody

(2ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Goat Anti-PON2 Polyclonal Antibody – Cat# MBS423637

Other Notes

Small volumes of anti-PON2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PON2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
serum paraoxonase/arylesterase 2 isoform 1
NCBI Official Synonym Full Names
paraoxonase 2
NCBI Official Symbol
PON2
UniProt Protein Name
Serum paraoxonase/arylesterase 2
UniProt Synonym Protein Names
Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2
UniProt Gene Name
PON2
UniProt Synonym Gene Names
PON 2; A-esterase 2
UniProt Entry Name
PON2_HUMAN
NCBI Protein Information
serum paraoxonase/arylesterase 2

NCBI Summary for PON2

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for PON2

PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.81; Motility/polarity/chemotaxis; EC 3.1.1.2; Hydrolase

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: extracellular region; lysosome; mitochondrion; nucleus; plasma membrane

Molecular Function: arylesterase activity; identical protein binding; metal ion binding

Biological Process: aromatic compound catabolic process; response to oxidative stress; response to toxin
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000