• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

HSD17B3 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423643

MBS423643 is an antibody targeting HSD17B3. Also known as Goat anti-HSD17B3 (aa141-155) Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HSD17B3, Polyclonal Antibody
Full Product Name
Goat anti-HSD17B3 (aa141-155) Antibody
Product Gene Name
anti-HSD17B3 antibody
Product Synonym Gene Name
HSD17B3
Product Synonym Names
HSD17B3; hydroxysteroid (17-beta) dehydrogenase 3; EDH17B3; SDR12C2; 17-beta-HSD 3; 17-beta-HSD3; 17-beta-hydroxysteroid dehydrogenase type 3; short chain dehydrogenase/reductase family 12C, member 2; testicular 17-beta-hydroxysteroid dehydrogenase; testo; HSD17B3 antibody; hydroxysteroid (17-beta) dehydrogenase 3 antibody; EDH17B3 antibody; SDR12C2 antibody; 17-beta-HSD 3 antibody; 17-beta-HSD3 antibody; 17-beta-hydroxysteroid dehydrogenase type 3 antibody; short chain dehydrogenase/reductase family 12C; member 2 antibody; testicular 17-beta-hydroxysteroid dehydrogenase antibody; testo antibody; HSD17B3 (aa141-155)
Immunogen Sequence
SHFLNAPDEI QSLIH
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
HSD17B3 peptide (MBS428733) is used for blocking the activity of HSD17B3 antibody (MBS423643)
Molecular Weight
29,109 Da
OMIM
264300
Immunogen
Peptide with sequence C-SHFLNAPDEIQSLIH, from the internal region of the protein sequence according to NP_000188.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-HSD17B3 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-HSD17B3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 33kDa band observed in Human Testis lysates (calculated MW of 34.5kDa according to NP_000188.1). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-HSD17B3 antibody

(2ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-HSD17B3 Polyclonal Antibody – Cat# MBS423643

Other Notes

Small volumes of anti-HSD17B3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD17B3. It may not necessarily be applicable to this product.

NCBI GI #
4557649
NCBI GeneID
3293
NCBI Accession #
NP_000188.1
UniProt Secondary Accession #
Q5U0Q6
UniProt Related Accession #
P37058
GenBank Nucleotide #
NM_000197.1
NCBI Official Full Name
testosterone 17-beta-dehydrogenase 3
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 3
NCBI Official Symbol
HSD17B3
NCBI Official Synonym Symbols
EDH17B3; SDR12C2
UniProt Protein Name
Testosterone 17-beta-dehydrogenase 3
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase
Protein Family
Testosterone 17-beta-dehydrogenase
UniProt Gene Name
HSD17B3
UniProt Synonym Gene Names
EDH17B3; SDR12C2; 17-beta-HSD 3
UniProt Entry Name
DHB3_HUMAN
NCBI Protein Information
testosterone 17-beta-dehydrogenase 3

NCBI Summary for HSD17B3

This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for HSD17B3

HSD17B3: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH). These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: EC 1.1.1.64; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; testosterone 17-beta-dehydrogenase (NADP+) activity

Biological Process: androgen biosynthetic process; male genitalia development

Disease: 17-beta Hydroxysteroid Dehydrogenase Iii Deficiency
Show more

Research Articles on HSD17B3

1. Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HSD17B3 antibody

 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones Pathway antibodies  Metabolism Of Steroid Hormones Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram

Diseases associated with anti-HSD17B3 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >31 publications with HSD17B3 and Congenital Abnormalities
 Disorders of Sex Development Antibodies  >30 publications with HSD17B3 and Disorders of Sex Development
 Genital Diseases, Male Antibodies  >19 publications with HSD17B3 and Genital Diseases, Male
 Prostatic Neoplasms Antibodies  >11 publications with HSD17B3 and Prostatic Neoplasms
 Hyperplasia Antibodies  >6 publications with HSD17B3 and Hyperplasia
 17-Hydroxysteroid Dehydrogenase Deficiency Antibodies  >4 publications with HSD17B3 and 17-Hydroxysteroid Dehydrogenase Deficiency
 Testicular Diseases Antibodies  >4 publications with HSD17B3 and Testicular Diseases
 Infertility, Male Antibodies  >3 publications with HSD17B3 and Infertility, Male
 Prenatal Exposure Delayed Effects Antibodies  >3 publications with HSD17B3 and Prenatal Exposure Delayed Effects
 Ovarian Diseases Antibodies  >3 publications with HSD17B3 and Ovarian Diseases

Organs/Tissues associated with anti-HSD17B3 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >40 publications with HSD17B3 and Testis
 Brain Antibodies  >9 publications with HSD17B3 and Brain
 Placenta Antibodies  >2 publications with HSD17B3 and Placenta
 Bone Antibodies  >1 publications with HSD17B3 and Bone
 Uncharacterized Tissue Antibodies  >1 publications with HSD17B3 and Uncharacterized Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000