PRKACA Antibody – Goat Polyclonal

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.

Protein type: EC 2.7.11.11; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; PKA family

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: AMP-activated protein kinase complex; cAMP-dependent protein kinase complex; centrosome; cytosol; Golgi apparatus; membrane; mitochondrion; neuromuscular junction; neuron projection; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: ATP binding; cAMP-dependent protein kinase activity; protein binding; protein complex binding; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: activation of protein kinase A; blood coagulation; cytosolic calcium ion homeostasis; G2/M transition of mitotic cell cycle; lipoprotein metabolic process; mesoderm formation; mRNA processing; negative regulation of meiotic cell cycle; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell proliferation; positive regulation of protein export from nucleus; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cellular respiration; regulation of heart rate; regulation of osteoblast differentiation; regulation of protein binding; regulation of synaptic transmission, glutamatergic; renal water homeostasis; sperm capacitation; stimulatory C-type lectin receptor signaling pathway