(0.1ug/ml) staining of Human Cerebellum (A), Mouse (B), Rat (C) and Pig (D) Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

GABRG2 Antibody

Name: GABRG2 Antibody; Dog-Reactive; Dog-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS423792
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423792

MBS423792 is an antibody targeting GABRG2. Also known as Goat anti-GABRG2 (aa384-396) Antibody. Reactive in Human, Mouse, Rat, PigExpected from sequence similarity: Dog, Cow. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GABRG2, Antibody

Full Product Name

Goat anti-GABRG2 (aa384-396) Antibody

Product Gene Name

anti-GABRG2 antibody

Product Synonym Names

GABRG2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; CAE2; ECA2; GEFSP3; GABA(A) receptor subunit gamma-2; GABA(A) receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2

Species Reactivity

Human, Mouse, Rat, Pig
Expected from sequence similarity: Dog, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

59.3kDa; 55.0kDa; 54.0kDa; 55.2kDa

OMIM

137164

3D Structure

ModBase 3D Structure for P18507

Immunogen Sequence

Peptide with sequence C-KAPTIDIRPRSAT, from the internal region of the protein sequence according to NP_944494.1; NP_000807.2; NP_944493.2.

Peptide Sequence + C

C-KAPTIDIRPRSAT

Epitope

Internal Region

Note

This antibody is expected to recognize all three reported isoforms (NP_944494.1; NP_000807.2; NP_944493.2).

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-GABRG2 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-GABRG2 antibody

Pep-ELISA: antibody detection limit dilution 1:16000.
WB: Approx 60kDa band observed in Human, Mouse, Rat and Pig Brain lysates. Recommended concentration: 0.1-0.3ug/ml.

Other Notes

Small volumes of anti-GABRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GABRG2. It may not necessarily be applicable to this product.

NCBI GI #

38788155

NCBI GeneID

2566

NCBI Accession #

NP_944494.1

NCBI Related Accession #

NP_000807.2; NP_944493.2; NP_032099.1; NP_899156.1; XP_003134135.1

UniProt Primary Accession #

P18507

UniProt Secondary Accession #

Q6GRL6; Q6PCC3; Q9UDB3; Q9UN15; F5HB82

UniProt Related Accession #

P18507

GenBank Nucleotide #

NM_198904.2

NCBI Official Full Name

gamma-aminobutyric acid receptor subunit gamma-2 isoform 1

NCBI Official Synonym Full Names

gamma-aminobutyric acid type A receptor gamma2 subunit

NCBI Official Symbol

GABRG2

NCBI Official Synonym Symbols

CAE2; ECA2; GEFSP3

UniProt Protein Name

Gamma-aminobutyric acid receptor subunit gamma-2

UniProt Synonym Protein Names

GABA(A) receptor subunit gamma-2

Protein Family

Gamma-aminobutyric acid receptor

UniProt Gene Name

GABRG2

NCBI Protein Information

gamma-aminobutyric acid receptor subunit gamma-2

NCBI Summary for GABRG2

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for GABRG2

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Research Articles on GABRG2

1. Differential GABRG2 structure disturbances are correlated with disease severity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GABRG2 antibody

Products by Pathway	Pathway Diagram
GABA A Receptor Activation Pathway antibodies	GABA A Receptor Activation Pathway Diagram
GABA Receptor Activation Pathway antibodies	GABA Receptor Activation Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Ligand-gated Ion Channel Transport Pathway antibodies	Ligand-gated Ion Channel Transport Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GABRG2 antibody

Disease Name	Pubmed Publications
Epilepsy Antibodies	>144 publications with GABRG2 and Epilepsy
Nervous System Diseases Antibodies	>143 publications with GABRG2 and Nervous System Diseases
Brain Diseases Antibodies	>120 publications with GABRG2 and Brain Diseases
Seizures Antibodies	>106 publications with GABRG2 and Seizures
Seizures, Febrile Antibodies	>81 publications with GABRG2 and Seizures, Febrile
Epilepsy, Absence Antibodies	>41 publications with GABRG2 and Epilepsy, Absence
Substance-Related Disorders Antibodies	>17 publications with GABRG2 and Substance-Related Disorders
Alcoholism Antibodies	>13 publications with GABRG2 and Alcoholism
Anxiety Disorders Antibodies	>12 publications with GABRG2 and Anxiety Disorders
Depressive Disorder Antibodies	>6 publications with GABRG2 and Depressive Disorder

Organs/Tissues associated with anti-GABRG2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>125 publications with GABRG2 and Brain
Nerve Antibodies	>44 publications with GABRG2 and Nerve
Kidney Antibodies	>16 publications with GABRG2 and Kidney
Muscle Antibodies	>3 publications with GABRG2 and Muscle
Eye Antibodies	>1 publications with GABRG2 and Eye