Rabbit Anti-GFM2 Antibody – Cat# MBS004238

GFM2 Antibody – Rabbit

Name: GFM2 Antibody; Rabbit; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS004238
Price: 595 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS004238

MBS004238 is an antibody targeting GFM2. Also known as Rabbit GFM2 Antibody. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GFM2, Antibody

Full Product Name

Rabbit GFM2 Antibody

Product Gene Name

anti-GFM2 antibody

Host

Rabbit

Species Reactivity

Human

Form/Format

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Concentration

1 mg/ml (lot specific)

Molecular Weight

86,601 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (74017031..74063042, complement). Location: 5q13

OMIM

606544

3D Structure

ModBase 3D Structure for Q969S9

Applications Tested/Suitable for anti-GFM2 antibody

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

Other Notes

Small volumes of anti-GFM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GFM2. It may not necessarily be applicable to this product.

NCBI GI #

19923640

NCBI GeneID

84340

NCBI Accession #

NP_115756.2

UniProt Primary Accession #

Q969S9

UniProt Secondary Accession #

Q8N6D8; Q8WYI0; Q9H6Z1; A0AR28

UniProt Related Accession #

Q969S9

GenBank Nucleotide #

NM_032380.3

NCBI Official Full Name

ribosome-releasing factor 2, mitochondrial isoform 1

NCBI Official Synonym Full Names

G elongation factor, mitochondrial 2

NCBI Official Symbol

GFM2

NCBI Official Synonym Symbols

EFG2; RRF2; MRRF2; hEFG2; MST027; RRF2mt; EF-G2mt; mEF-G 2

UniProt Protein Name

Ribosome-releasing factor 2, mitochondrial

UniProt Synonym Protein Names

Elongation factor G 2, mitochondrial; EF-G2mt; mEF-G 2; Elongation factor G2

UniProt Gene Name

GFM2

UniProt Synonym Gene Names

EFG2; RRF2mt; EF-G2mt; mEF-G 2; hEFG2

UniProt Entry Name

RRF2M_HUMAN

NCBI Protein Information

ribosome-releasing factor 2, mitochondrial; MSTP027; mitochondrial elongation factor G2; elongation factor G 2, mitochondrial; mitochondrial ribosome recycling factor 2

NCBI Summary for GFM2

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in at least three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for GFM2

GFM2: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: mitochondrial matrix

Molecular Function: GTPase activity; GTP binding; translation elongation factor activity

Biological Process: mitochondrial translation; organelle organization and biogenesis; ribosome disassembly

Research Articles on GFM2

1. These findings constitute the first reported phenotype associated with SNPs in the EF-G2mt gene and implicate the human EF-G2mt gene as a pharmacogenetic candidate gene for statin toxicity in humans

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.