Rabbit Anti-THOC4 Antibody – Cat# MBS004271

THOC4 Antibody – Rabbit

Name: THOC4 Antibody; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS004271
Price: 595 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS004271

MBS004271 is an antibody targeting THOC4. Also known as Rabbit THOC4 Antibody. Reactive in Human, mouse, rat. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

THOC4, Antibody

Full Product Name

Rabbit THOC4 Antibody

Product Gene Name

anti-THOC4 antibody

Host

Rabbit

Species Reactivity

Human, mouse, rat

Form/Format

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Concentration

1 mg/ml (lot specific)

Molecular Weight

26,888 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (79845711..79849462, complement). Location: 17q25.3

OMIM

604171

3D Structure

ModBase 3D Structure for Q86V81

Applications Tested/Suitable for anti-THOC4 antibody

ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-THOC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for THOC4. It may not necessarily be applicable to this product.

NCBI GI #

238776833

NCBI GeneID

10189

NCBI Accession #

NP_005773.3

UniProt Primary Accession #

Q86V81

UniProt Secondary Accession #

O43672

UniProt Related Accession #

Q86V81

GenBank Nucleotide #

NM_005782.3

NCBI Official Full Name

THO complex subunit 4

NCBI Official Synonym Full Names

Aly/REF export factor

NCBI Official Symbol

ALYREF

NCBI Official Synonym Symbols

ALY; BEF; REF; THOC4; ALY/REF

UniProt Protein Name

THO complex subunit 4

UniProt Synonym Protein Names

Ally of AML-1 and LEF-1; Aly/REF export factor; Transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF

UniProt Gene Name

ALYREF

UniProt Synonym Gene Names

ALY; BEF; THOC4; Tho4

UniProt Entry Name

THOC4_HUMAN

NCBI Protein Information

THO complex subunit 4; tho4; THO complex 4; bZIP enhancing factor; ally of AML-1 and LEF-1; bZIP-enhancing factor BEF; transcriptional coactivator Aly/REF

NCBI Summary for THOC4

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]

UniProt Comments for THOC4

THOC4: a chaperone protein that promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains thus promoting transcriptional activation. Plays a role in mRNA processing and export. May function as scaffold that mediates interactions between proteins and/or RNA. Integral part of the THO/TREX complex that is recruited to transcribed genes and travels with the RNA polymerase during elongation. Is part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Nuclear localization, translocates to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Two differentially spliced isoforms have been described.

Protein type: Spliceosome; Transcription, coactivator/corepressor; RNA-binding; Chaperone

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; nuclear speck; cytosol; nucleus

Molecular Function: protein binding; nucleotide binding; single-stranded DNA binding

Biological Process: osteoblast differentiation; nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA export from nucleus; positive regulation of RNA elongation; regulation of DNA recombination; RNA splicing; gene expression; intronless viral mRNA export from host nucleus; mRNA 3'-end processing; termination of RNA polymerase II transcription; replication fork processing

Research Articles on THOC4

1. High ALY expression is associated with lymph node metastasis in oral squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-THOC4 antibody

Reference Product	PubMed Publications
DDX39B antibody	>9 publications with THOC4 and DDX39B
LEF1 antibody	>2 publications with THOC4 and LEF1
DDX39A antibody	>2 publications with THOC4 and DDX39A
MAGOH antibody	>1 publications with THOC4 and MAGOH

Pathways associated with anti-THOC4 antibody

Products by Pathway	Pathway Diagram
Cleavage Of Growing Transcript In The Termination Region Pathway antibodies	Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
Exon Junction Complex (EJC) Pathway antibodies	Exon Junction Complex (EJC) Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies	Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
RNA Polymerase II Transcription Pathway antibodies	RNA Polymerase II Transcription Pathway Diagram
RNA Polymerase II Transcription Termination Pathway antibodies	RNA Polymerase II Transcription Termination Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram

Diseases associated with anti-THOC4 antibody

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>1 publications with THOC4 and Neoplasm Metastasis
Immune System Diseases Antibodies	>1 publications with THOC4 and Immune System Diseases
Breast Neoplasms Antibodies	>1 publications with THOC4 and Breast Neoplasms
Skin Diseases Antibodies	>1 publications with THOC4 and Skin Diseases

Organs/Tissues associated with anti-THOC4 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>3 publications with THOC4 and Skin
Lung Antibodies	>1 publications with THOC4 and Lung
Lymph Node Antibodies	>1 publications with THOC4 and Lymph Node
Testis Antibodies	>1 publications with THOC4 and Testis