AQP1: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein type: Transporter; Transporter, aquaporin family; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: nuclear membrane; neuron projection; brush border membrane; integral to plasma membrane; cell; basolateral plasma membrane; integral to membrane; dense core granule membrane; membrane; axon; apical part of cell; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; nerve terminal; nucleus; sarcolemma; brush border
Molecular Function: ephrin receptor binding; potassium channel activity; water transporter activity; intracellular cGMP activated cation channel activity; ammonium transmembrane transporter activity; transporter activity; glycerol transmembrane transporter activity; potassium ion transmembrane transporter activity; transmembrane transporter activity; water channel activity; nitric oxide transporter activity; glycerol channel activity
Biological Process: cGMP biosynthetic process; glycerol transport; wound healing; water transport; cellular response to stress; carbon dioxide transport; negative regulation of caspase activity; sensory perception of pain; positive regulation of saliva secretion; water homeostasis; positive regulation of fibroblast proliferation; organic cation transport; nitric oxide transport; transport; cellular homeostasis; transmembrane transport; lipid digestion; potassium ion transport; secretion by cell; response to drug; cellular water homeostasis; secretory granule organization and biogenesis; glomerular filtration; ammonium transport; positive regulation of angiogenesis; renal water transport; camera-type eye morphogenesis; adrenocorticotropin hormone secretion; establishment and/or maintenance of actin cytoskeleton polarity; cell volume homeostasis; positive regulation of cell migration; negative regulation of apoptosis
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