JIP1 Antibody – Rabbit

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

JIP1: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade. Required for JNK activation in response to excitotoxic stress. Causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and by inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly or indirectly regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: endoplasmic reticulum membrane; perinuclear region of cytoplasm; mitochondrial membrane; cytoplasm; synapse; nucleus; cytosol

Molecular Function: JUN kinase binding; identical protein binding; MAP-kinase scaffold activity; protein binding; protein kinase inhibitor activity; kinesin binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding

Biological Process: vesicle-mediated transport; negative regulation of JNK activity; regulation of transcription, DNA-dependent; positive regulation of signal transduction; regulation of JNK cascade; JUN phosphorylation

Disease: Diabetes Mellitus, Noninsulin-dependent