E2 (HCV) (E2) Recombinant Protein

Viral protein purified from 293 cell culture.

The hepatitis C virus (HCV) is a small, enveloped, single-stranded, positive-sense RNA virus. HCV has a high rate of replication with approximately one trillion particles produced ach day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. There are seven major genotypes of HCV with several subtypes within each genotype.

The viral RNA codes for a large polyprotein of approx. 3100 amino acids, which is posttranslationally processed by cellular and viral proteases. The N-terminus encompasses the structural proteins core andtwo glycoproteins (E1,E2);the C-terminus encompasses the p7 protein and the nonstructural (NS) proteins NS2, NS3, NS4A, NS4B, NS5A and NS5B.

Small volumes of E2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Hepatitis C virus HCV is a leading cause of liver transplant. It is also frequently detected in HIV-positive individuals. Unlike human papillomavirus or vaccinia virus which are have DNA genomes, HCV is a highly mutable RNA virus. This virus invades most cell types and HCV positive patients have high titers. High viral loads are associated with cancer - see abstract free full text publication listed on data sheet. The HCV E2 protein is one of two coat proteins and is frequently used to teat cells and sera for infection. For the production of antibodies for ELISA pairs or primary anti HCV antibody selection, MyBiosource offers a highly purified recombinant 50 ug vial of HGHe2T protein. This economical product is ideal when combined with other human recombinant proteins to create an array of exciting experiments. Some are listed when you buy on info E2 215 data sheet.