Gp120 (HIV-1/Subtype Crf07_bc/CH181) (gp120) Recombinant Protein

Description: 6xHis tagged gp120 (HIV-1/Subtype CRF07_BC/CH181) (aa 32-515) (Genebank No. ABL67456)
Envelop protein gp120 expressed and purified from 293 cell culture
Introduction: Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.

Small volumes of gp120 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS434206 is a recombinant protein targeting gp120. Also known as gp120 (HIV-1/Subtype CRF07_BC/CH181) (aa 32-515). Host: 293 cell culture.