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ETEA Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS435166

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD… More details

$435 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ETEA, Monoclonal Antibody
Full Product Name
ETEA Mouse mAb
Product Gene Name
anti-ETEA antibody
Product Synonym Gene Name
FAF2
Product Synonym Names
expressed in T-cells and eosinophils in atopic dermatitis; FAF2; Fas associated factor family member 2; FAS-associated factor 2; KIAA0887; Protein ETEA; protein expressed in T-cells and eosinophils in atopic dermatitis; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3B; 2210404D11Rik; AI462440; ETEA; FAF2; KIAA0887; mKIAA0887; UBXD8; UBXN3B
Clonality
Monoclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Preparation and Storage
Store at -20 degree C. Stable for one year from the date of shipment.
Molecular Weight
Predicted MW: 53kDa
3D Structure
ModBase 3D Structure for Q96CS3
Source Note
This monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of human FAF2

Product Categories/Family for anti-ETEA antibody

Cell Marker; Subcellular Marker; Membrane
Applications Tested/Suitable for anti-ETEA antibody
Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-ETEA antibody
WB: 1:1000-1:5000
IP: 10 tests
FC/FACS: 1:100-1:200

Western Blot (WB) of anti-ETEA antibody

Mouse Anti-ETEA Monoclonal Antibody – Cat# MBS435166

Immunoprecipitation (IP) of anti-ETEA antibody

FAF2 was immunoprecipitated from 1mg of Jurkat cells membrane fraction, blotted with M25099 of 10 ug. Western blot was performed from the immunoprecipitate using M25099 at 1/1000 dilution. Anti-Mouse-IgG(HRP), specific to the non-reduced form of IgG, was used as secondary antibody at 1/10000 dilution. Lane 1: Jurkat cells membrane fraction. Lane2: IP product of Jurkat cells membrane fraction.

Predicted band size : 53 KDa
Observed band size : 53 KDa

Blocking and dilution buffer and concentration:5% milk/TBST.
Mouse Anti-ETEA Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS435166

Flow Cytometry (FC/FACS) of anti-ETEA antibody

Flow cytometric analysis of 2% paraformaldehyde-fixed Jurkat (Human T cell leukemia cells from peripheral blood) cells labeling FAF2 with M25099 at 1/200 dilution (red) compared with a mouse monoclonal IgG isotype control (black) and an unlabelled control (cells without incubation with primary antibody, blue). Goat anti-mouse IgG (FITC) at 1/300 dilution was used as the secondary antibody.
Mouse Anti-ETEA Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS435166

Other Notes

Small volumes of anti-ETEA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ETEA purchase

MBS435166 is an antibody targeting ETEA. Also known as ETEA Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ETEA. It may not necessarily be applicable to this product.

NCBI GI #
24797106
NCBI GeneID
23197
NCBI Accession #
NP_055428.1
UniProt Primary Accession #
Q96CS3
UniProt Secondary Accession #
O94963; Q8IUF2; Q9BRP2; Q9BVM7
UniProt Related Accession #
Q96CS3
GenBank Nucleotide #
NM_014613.2
NCBI Official Full Name
FAS-associated factor 2
NCBI Official Synonym Full Names
Fas associated factor family member 2
NCBI Official Symbol
FAF2
NCBI Official Synonym Symbols
ETEA; UBXD8; UBXN3B
UniProt Protein Name
FAS-associated factor 2
UniProt Synonym Protein Names
Protein ETEA; UBX domain-containing protein 3B; UBX domain-containing protein 8
Protein Family
FAS-associated factor
UniProt Gene Name
FAF2
UniProt Synonym Gene Names
ETEA; KIAA0887; UBXD8; UBXN3B
NCBI Protein Information
FAS-associated factor 2

UniProt Comments for ETEA

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).
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Research Articles on ETEA

1. UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-ETEA antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1 publications with ETEA and Vascular
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