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Caspase-2 (CASP-2) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS435300

Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. Caspase 2 proteolytically cleaves other proteins. It belongs to a family of cysteine proteases called caspases that cleave proteins only at an amino acid following an… More details

$435 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Caspase-2 (CASP-2), Monoclonal Antibody
Full Product Name
Caspase-2 mAb
Product Gene Name
Product Synonym Names
Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1; ICH1; NEDD2
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preparation and Storage
Store at +4 degree C short term. Store at -20 degree C long term. Avoid freeze / thaw cycle.
Molecular Weight
48; 30; 12kDa
3D Structure
ModBase 3D Structure for P42575
Source Note
This monoclonal antibody is produced by immunizing animals with a polypeptide corresponding to Caspase-2 protein.
Applications Tested/Suitable for anti-CASP-2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Application Notes for anti-CASP-2 antibody
WB: 1:500-2000
IHC 50-200
ICC/IF: 50-200

Western Blot (WB) of anti-CASP-2 antibody

Rabbit Anti-CASP-2 Monoclonal Antibody – Cat# MBS435300

Immunohistochemistry (IHC) of anti-CASP-2 antibody

Rabbit Anti-CASP-2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS435300

Immunofluorescence (IF) of anti-CASP-2 antibody

Rabbit Anti-CASP-2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS435300

Other Notes

Small volumes of anti-CASP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASP-2 purchase

MBS435300 is an antibody targeting CASP-2. Also known as Caspase-2 mAb. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CASP-2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
caspase-2 isoform 2
NCBI Official Synonym Full Names
caspase 2
NCBI Official Symbol
CASP2
NCBI Official Synonym Symbols
ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57
UniProt Protein Name
Caspase-2
UniProt Synonym Protein Names
Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2
Protein Family
UniProt Gene Name
CASP2
UniProt Synonym Gene Names
ICH1; NEDD2; CASP-2; NEDD-2
NCBI Protein Information
caspase-2

NCBI Summary for CASP-2

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
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UniProt Comments for CASP-2

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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