C1 INH Antibody – Mouse Monoclonal

C1 INH (C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation. The protein is an acute-phase protein that circulates in blood at levels of around 0.25 g/L. The levels rise 2-fold during inflammation. C1 INH irreversibly binds to and inactivates C1r and C1s proteases in the C1 complex of classical pathway of complement. MASP-1 and MASP-2 proteases in MBL complexes of the lectin pathway are also inactivated. This way, it prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. Although named after its complement inhibitory activity, the protein also inhibits proteases of the fibrinolytic, clotting, and kinin pathways. The protein is the most important physiological inhibitor of plasma kallikrein, fXIa, and fXIIa.

Small volumes of anti-C1 INH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS435466 is an antibody targeting C1 INH. Also known as C1 INH Mouse mAb. Reactive in Homo Sapiens. Host: Mouse.