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MRP1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4380115

MBS4380115 is an antibody targeting MRP1. Also known as MRP1/ABCC1 (Multidrug Resistance Related Protein 1). Reactive in Human. Others not known.. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MRP1/ABCC1 (Multidrug Resistance Related Protein 1), Monoclonal Antibody
Full Product Name
MRP1/ABCC1 (Multidrug Resistance Related Protein 1)
Product Gene Name
anti-MRP1 antibody
Product Synonym Gene Name
ABCC1
Product Synonym Names
ABC29; ABCC1; ATP binding cassette sub family C (CFTR/MRP) member 1; ATP-binding cassette sub-family C member 1; GSX; Leukotriene C(4) transporter; LTC4 transporter; Multidrug resistance-associated protein 1 (MRP1)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
MRP1/1343
Host
Mouse
Species Reactivity
Human. Others not known.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
190kDa
3D Structure
ModBase 3D Structure for P33527
Immunogen
Recombinant human full-length ABCC1
Cellular Localization
Cytoplasmic and Cell Surface
Hu-chromosome Location
16p13.11
Positive Control
A549 cells. Colon, Endometrium, Ovary. Testis or Tonsil.
Applications Tested/Suitable for anti-MRP1 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
Application Notes for anti-MRP1 antibody
FC/FACS: 0.5-1ug/million cells
IF: 0.5-1ug/ml
WB: 0.5-1ug/ml
IHC-F: 1-2ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-MRP1 antibody

Formalin-fixed, paraffin-embedded Human Tonsil stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).
Mouse Anti-MRP1 Monoclonal Antibody – Cat# MBS4380115

Immunohistochemistry (IHC) of anti-MRP1 antibody

Formalin-fixed, paraffin-embedded Human Pancreas stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).
Mouse Anti-MRP1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4380115

Immunohistochemistry (IHC) of anti-MRP1 antibody

Formalin-fixed, paraffin-embedded Human Duodenum stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).
Mouse Anti-MRP1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4380115

Immunohistochemistry (IHC) of anti-MRP1 antibody

Formalin-fixed, paraffin-embedded Human Rectal Carcinoma stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).
Mouse Anti-MRP1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4380115

Immunohistochemistry (IHC) of anti-MRP1 antibody

Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).
Mouse Anti-MRP1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4380115

Product References and Citations for anti-MRP1 antibody

Faneyte IF, Kristel PM, van de Vijver MJ. Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer. Anticancer Res. 2004; 24(5A):2931-9.

Other Notes

Small volumes of anti-MRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MRP1. It may not necessarily be applicable to this product.

NCBI GI #
134142337
NCBI GeneID
4363
NCBI Accession #
NP_004987.2
UniProt Primary Accession #
P33527
UniProt Secondary Accession #
O14819; O43333; P78419; Q59GI9; Q9UQ97; Q9UQ99; Q9UQA0; A3RJX2; C9JPJ4
UniProt Related Accession #
P33527
GenBank Nucleotide #
NM_004996.3
NCBI Official Full Name
multidrug resistance-associated protein 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 1
NCBI Official Symbol
ABCC1
NCBI Official Synonym Symbols
MRP; ABCC; GS-X; MRP1; ABC29
UniProt Protein Name
Multidrug resistance-associated protein 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
Protein Family
37S ribosomal protein
UniProt Gene Name
ABCC1
UniProt Synonym Gene Names
MRP; MRP1; LTC4 transporter
NCBI Protein Information
multidrug resistance-associated protein 1

NCBI Summary for MRP1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
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UniProt Comments for MRP1

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
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Research Articles on MRP1

1. icaritin (ICT) decreased the mRNA and protein levels of multidrug resistance-associated protein 1 (MRP1) in MG-63 doxorubicin-resistant (MG-63/DOX) cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MRP1 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram

Diseases associated with anti-MRP1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >44 publications with MRP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >28 publications with MRP1 and Lung Neoplasms
 Brain Diseases Antibodies  >27 publications with MRP1 and Brain Diseases
 Adenocarcinoma Antibodies  >27 publications with MRP1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >27 publications with MRP1 and Nervous System Diseases
 Liver Diseases Antibodies  >23 publications with MRP1 and Liver Diseases
 Disease Models, Animal Antibodies  >20 publications with MRP1 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >16 publications with MRP1 and Ovarian Neoplasms
 Liver Neoplasms Antibodies  >15 publications with MRP1 and Liver Neoplasms
 Colorectal Neoplasms Antibodies  >13 publications with MRP1 and Colorectal Neoplasms

Organs/Tissues associated with anti-MRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >127 publications with MRP1 and Blood
 Brain Antibodies  >72 publications with MRP1 and Brain
 Liver Antibodies  >65 publications with MRP1 and Liver
 Lung Antibodies  >55 publications with MRP1 and Lung
 Kidney Antibodies  >45 publications with MRP1 and Kidney
 Vascular Antibodies  >23 publications with MRP1 and Vascular
 Intestine Antibodies  >22 publications with MRP1 and Intestine
 Testis Antibodies  >15 publications with MRP1 and Testis
 Skin Antibodies  >13 publications with MRP1 and Skin
 Placenta Antibodies  >12 publications with MRP1 and Placenta
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