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NGF-Receptor (P75)/CD271 (NGFR) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4380135

MBS4380135 is an antibody targeting NGFR. Also known as NGF-Receptor (p75)/CD271 (Soft Tissue Tumor Marker). Reactive in Human, Non-human Primates.Does not react with Mouse, Rat. Others not known.. Host: Rabbit. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NGF-Receptor (p75)/CD271 (NGFR), Monoclonal Antibody
Full Product Name
NGF-Receptor (p75)/CD271 (Soft Tissue Tumor Marker)
Product Gene Name
anti-NGFR antibody
Product Synonym Gene Name
CD271
Product Synonym Names
CD271; Gp80-LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor (NGFR); p75 ICD; p75 Neurotrophin receptor; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)
Clonality
Monoclonal
Isotype
IgG
Clone Number
NGFR/1997R
Host
Rabbit
Species Reactivity
Human, Non-human Primates.
Does not react with Mouse, Rat. Others not known.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
75kDa
3D Structure
ModBase 3D Structure for P08138
Immunogen
Recombinant full-length human p75 NGFR protein
Cellular Localization
Cell Surface and Cytoplasmic
Hu-chromosome Location
17q21-22
Positive Control
Neuronal axons, Schwann cells, and perineural cells of peripheral nerves, or tumors of nerve sheath differentiation e.g. Schwannoma, Neurofibroma. Soma and axons of sensory neurons, and ganglionic satellite cells. Melanomas.
Applications Tested/Suitable for anti-NGFR antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-NGFR antibody
FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 0.5-1ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-NGFR antibody

Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR Rabbit Recombinant Monoclonal Antibody (NGFR/1997R).
Rabbit Anti-NGFR Monoclonal Antibody – Cat# MBS4380135

SDS-Page of anti-NGFR antibody

SDS-PAGE Analysis of Purified NGFR Rabbit Recombinant Monoclonal Antibody (NGFR/1997R).
Rabbit Anti-NGFR Monoclonal Antibody, SDS-Page – Cat# MBS4380135

Product References and Citations for anti-NGFR antibody

Wang, W., et al. 2009. Patterns of expression and function of the p75NGFR protein in pancreatic cancer cells and tumours. Eur. J. Surg. Oncol. 35: 826-832. Soland, T.M., et al. 2008. Nerve growth factor receptor (p75NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma. Histopathology 53: 62-72.

Other Notes

Small volumes of anti-NGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.

NCBI GI #
4505393
NCBI GeneID
4804
NCBI Accession #
NP_002498.1
UniProt Primary Accession #
P08138
UniProt Secondary Accession #
B2R961; B4E096
UniProt Related Accession #
P08138
GenBank Nucleotide #
NM_002507.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 16
NCBI Official Synonym Full Names
nerve growth factor receptor
NCBI Official Symbol
NGFR
NCBI Official Synonym Symbols
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 16
UniProt Synonym Protein Names
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
NGFR
UniProt Synonym Gene Names
TNFRSF16; NGF receptor
NCBI Protein Information
tumor necrosis factor receptor superfamily member 16

NCBI Summary for NGFR

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
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UniProt Comments for NGFR

Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
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Research Articles on NGFR

1. High p75(NTR) expression is associated with esophageal squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NGFR antibody

 Reference Product  PubMed Publications
 NGF antibody  >232 publications with NGFR and NGF
 NTRK1 antibody  >101 publications with NGFR and NTRK1
 NTRK2 antibody  >30 publications with NGFR and NTRK2
 NTRK3 antibody  >17 publications with NGFR and NTRK3
 MAG antibody  >3 publications with NGFR and MAG
 NTF4 antibody  >3 publications with NGFR and NTF4
 MAPK1 antibody  >2 publications with NGFR and MAPK1
 GRB2 antibody  >2 publications with NGFR and GRB2
 RTN4R antibody  >2 publications with NGFR and RTN4R
 SHC1 antibody  >2 publications with NGFR and SHC1

Pathways associated with anti-NGFR antibody

 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Ceramide Signalling Pathway antibodies  Ceramide Signalling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
 NF-kB Is Activated And Signals Survival Pathway antibodies  NF-kB Is Activated And Signals Survival Pathway Diagram
 NFG And ProNGF Binds To P75NTR Pathway antibodies  NFG And ProNGF Binds To P75NTR Pathway Diagram

Diseases associated with anti-NGFR antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >158 publications with NGFR and Neoplasms
 Nervous System Diseases Antibodies  >116 publications with NGFR and Nervous System Diseases
 Brain Diseases Antibodies  >56 publications with NGFR and Brain Diseases
 Necrosis Antibodies  >40 publications with NGFR and Necrosis
 Neurodegenerative Diseases Antibodies  >34 publications with NGFR and Neurodegenerative Diseases
 Nerve Degeneration Antibodies  >31 publications with NGFR and Nerve Degeneration
 Inflammation Antibodies  >23 publications with NGFR and Inflammation
 Disease Models, Animal Antibodies  >23 publications with NGFR and Disease Models, Animal
 Mental Disorders Antibodies  >20 publications with NGFR and Mental Disorders
 Kidney Diseases Antibodies  >14 publications with NGFR and Kidney Diseases

Organs/Tissues associated with anti-NGFR antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >184 publications with NGFR and Brain
 Mixed Antibodies  >9 publications with NGFR and Mixed
 Spleen Antibodies  >3 publications with NGFR and Spleen
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