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Secretory Component/ECM1 (ECM1) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4380544

MBS4380544 is an antibody targeting ECM1. Also known as Secretory Component/ECM1. Reactive in Human, Rat. Others not known.. Host: Rabbit. Recombinant Rabbit Monoclonal Antibody More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Secretory Component/ECM1, Monoclonal Antibody
Full Product Name
Secretory Component/ECM1
Product Gene Name
anti-ECM1 antibody
Product Synonym Names
ECM1; Extracellular Matrix Protein 1; Secretory Component p85; URBWD
Clonality
Monoclonal
Isotype
IgG
Clone Number
ECM1/2889R
Host
Rabbit
Species Reactivity
Human, Rat. Others not known.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Specificity
This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
~80kDa
3D Structure
ModBase 3D Structure for Q16610
Immunogen
Recombinant full-length human ECM1 protein
Positive Control
Stomach, Lung, or Breast Tumor
Cellular Localization
Cell Surface and Cytoplasmic
Chromosome Location
1q21.2
Applications Tested/Suitable for anti-ECM1 antibody
Immunohistology (Formalin-Fixed)
Application Notes for anti-ECM1 antibody
Immunohistology (Formalin-Fixed): 0.5-1ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-ECM1 antibody

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Secretory Component Rabbit Recombinant Monoclonal (ECM1/2889R).
Rabbit Anti-ECM1 Monoclonal Antibody – Cat# MBS4380544

SDS-Page of anti-ECM1 antibody

SDS-PAGE Analysis of Purified Secretory Component Rabbit Recombinant Monoclonal (ECM1/2889R). Confirmation of Purity and Integrity of Antibody.
Rabbit Anti-ECM1 Monoclonal Antibody, SDS-Page – Cat# MBS4380544

Product References and Citations for anti-ECM1 antibody

Int. J. Cancer, 42, 638-641 (1988).; Bartek J et. al. Histochemistry 91:235-244 (1989).; Histochem J., 22, (1990).

Other Notes

Small volumes of anti-ECM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ECM1. It may not necessarily be applicable to this product.

NCBI GI #
322302700
NCBI GeneID
1893
NCBI Accession #
NP_001189787.1
UniProt Primary Accession #
Q16610
UniProt Secondary Accession #
O43266; Q5T5G4; Q5T5G5; Q5T5G6; Q8IZ60; A8K8S0; B4DW49; B4DY60
UniProt Related Accession #
Q16610
GenBank Nucleotide #
NM_001202858.1
NCBI Official Full Name
extracellular matrix protein 1 isoform 3
NCBI Official Synonym Full Names
extracellular matrix protein 1
NCBI Official Symbol
ECM1
NCBI Official Synonym Symbols
URBWD
UniProt Protein Name
Extracellular matrix protein 1
UniProt Synonym Protein Names
Secretory component p85
Protein Family
Extracellular matrix protein
UniProt Gene Name
ECM1
NCBI Protein Information
extracellular matrix protein 1

NCBI Summary for ECM1

This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
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UniProt Comments for ECM1

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.

Research Articles on ECM1

1. the present study demonstrated the association between ECM1 gene mutation and patients with LP. Patients with LP exhibited one homozygous point mutation (C220G) as previously reported, one novel homozygous mutation (c.508insCTG) and two heterozygous mutations (C220G/P.R481X and c.507delT/c.l473delT).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ECM1 antibody

 Reference Product  PubMed Publications
 FN1 antibody  >4 publications with ECM1 and FN1
 SPARC antibody  >4 publications with ECM1 and SPARC
 TIMP1 antibody  >4 publications with ECM1 and TIMP1
 EGF antibody  >4 publications with ECM1 and EGF
 THBS1 antibody  >3 publications with ECM1 and THBS1
 LGALS3BP antibody  >1 publications with ECM1 and LGALS3BP

Pathways associated with anti-ECM1 antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-ECM1 antibody

 Disease Name  Pubmed Publications
 Lipoid Proteinosis of Urbach and Wiethe Antibodies  >65 publications with ECM1 and Lipoid Proteinosis of Urbach and Wiethe
 Carcinoma Antibodies  >31 publications with ECM1 and Carcinoma
 Breast Neoplasms Antibodies  >16 publications with ECM1 and Breast Neoplasms
 Colitis, Ulcerative Antibodies  >11 publications with ECM1 and Colitis, Ulcerative
 Inflammation Antibodies  >10 publications with ECM1 and Inflammation
 Adenocarcinoma Antibodies  >10 publications with ECM1 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >9 publications with ECM1 and Carcinoma, Squamous Cell
 Disease Models, Animal Antibodies  >7 publications with ECM1 and Disease Models, Animal
 Infertility, Male Antibodies  >5 publications with ECM1 and Infertility, Male
 Neoplasms, Experimental Antibodies  >4 publications with ECM1 and Neoplasms, Experimental

Organs/Tissues associated with anti-ECM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >67 publications with ECM1 and Skin
 Blood Antibodies  >44 publications with ECM1 and Blood
 Vascular Antibodies  >23 publications with ECM1 and Vascular
 Brain Antibodies  >13 publications with ECM1 and Brain
 Bone Antibodies  >11 publications with ECM1 and Bone
 Thyroid Antibodies  >10 publications with ECM1 and Thyroid
 Connective Tissue Antibodies  >10 publications with ECM1 and Connective Tissue
 Muscle Antibodies  >9 publications with ECM1 and Muscle
 Kidney Antibodies  >9 publications with ECM1 and Kidney
 Lymph Node Antibodies  >7 publications with ECM1 and Lymph Node
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