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S100A2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4380681

MBS4380681 is an antibody targeting S100A2. Also known as S100A2/S100 Calcium Binding Protein A2. Reactive in Human. Others not tested.. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
S100A2/S100 Calcium Binding Protein A2, Monoclonal Antibody
Full Product Name
S100A2/S100 Calcium Binding Protein A2
Product Gene Name
Product Synonym Names
CAN19; MGC111539; S100L
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
CPTC-S100A2-2
Host
Mouse
Species Reactivity
Human. Others not tested.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Specificity
S100A2 belongs to the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A2 may function as a modulator against excess calcium accumulation in normal human mammary epithelial cells and also have a role in suppressing tumor cell growth. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. Cytoplasmic overexpression may also be of prognostic significance when observed in oral cancer patients, and the S100A2 has also been identified as significantly down-regulated in gastric cancer.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
11.12kDa
3D Structure
ModBase 3D Structure for P29034
Immunogen
Recombinant human full length protein
Positive Control
HACAT, BxPC3, and A431 cell lysates; Skin and squamous cell cervical carcinoma.
Cellular Localization
Nucleus and cytoplasm.
Chromosome Location
1q21.3
Applications Tested/Suitable for anti-S100A2 antibody
Western Blot (WB), Immunohistology (Formalin-Fixed)
Application Notes for anti-S100A2 antibody
WB: 0.5-1.0ug/ml
Immunohistology (Formalin-Fixed): 0.5-1ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-S100A2 antibody

Formalin-fixed, paraffin-embedded human Skin stained with S100A2 Mouse Monoclonal Antibody (CPTC-S100A2-2).
Mouse Anti-S100A2 Monoclonal Antibody – Cat# MBS4380681

Immunohistochemistry (IHC) of anti-S100A2 antibody

Formalin-fixed, paraffin-embedded human Placenta stained with S100A2 Mouse Monoclonal Antibody (CPTC-S100A2-2).
Mouse Anti-S100A2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4380681

Testing Data of anti-S100A2 antibody

Analysis of Protein Array containing more than 19,000 full-length human proteins using S100A2 Mouse Monoclonal Antibody (CPTC-S100A2-2).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Mouse Anti-S100A2 Monoclonal Antibody, Testing Data – Cat# MBS4380681

Product References and Citations for anti-S100A2 antibody

Wessels D, et al. PLoS ONE 12(3): e017340

Other Notes

Small volumes of anti-S100A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for S100A2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein S100-A2
NCBI Official Synonym Full Names
S100 calcium binding protein A2
NCBI Official Symbol
S100A2
NCBI Official Synonym Symbols
CAN19; S100L
UniProt Protein Name
Protein S100-A2
UniProt Synonym Protein Names
CAN19; Protein S-100L; S100 calcium-binding protein A2
Protein Family
UniProt Gene Name
S100A2
UniProt Synonym Gene Names
S100L
NCBI Protein Information
protein S100-A2

NCBI Summary for S100A2

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
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UniProt Comments for S100A2

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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