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IgG (Immunoglobulin Gamma Heavy Chain) (IGHG) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4380997

MBS4380997 is an antibody targeting IGHG. Also known as IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker). Reactive in Human. Host: Mouse. More details

$500 / 0.5 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IgG (Immunoglobulin Gamma Heavy Chain) (IGHG), Monoclonal Antibody
Full Product Name
IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker)
Product Gene Name
anti-IGHG antibody
Product Synonym Names
G1m Marker; G2m Marker; G3m Marker; G4m Marker; HDC; Heavy Chain Disease Protein; Human Immunglobulin G; Ig gamma1/2/3/4 Chain C Region; IGHG1; IGHG2; IGHG3; IGHG4; Immunoglobulin Heavy Constant 1/2/3/4
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
IG266
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purity/Purification
Purified Ab conjugated to CF488
Specificity
Recognizes a protein of 75kDa, identified as gamma heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), mu (IgM), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Preparation and Storage
Antibody with azide: store at 4 to 8 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
75kDa
OMIM
147100
3D Structure
ModBase 3D Structure for P01857
Positive Control
293T, Raji or hPBL cells. Tonsil or Spleen.
Immunogen
Purified human Ig Gamma Chain
Cellular Localization
Cytoplasm, Cell Surface and Secreted
Hu-chromosome Location
14q32.33
Applications Tested/Suitable for anti-IGHG antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-IGHG antibody
FC/FACS: 0.5-1ug/million cells
IF: 0.5-1ug/ml
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

SDS-Page of anti-IGHG antibody

SDS-PAGE Analysis Purified IgG Mouse Monoclonal Antibody (IG266). Confirmation of Integrity and Purity of Antibody.
Mouse Anti-IGHG Monoclonal Antibody – Cat# MBS4380997

Testing Data of anti-IGHG antibody

Analysis of Protein Array containing more than 19,000 full-length human proteins using Anti-IgG Mouse Monoclonal Antibody (IG266). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.
Mouse Anti-IGHG Monoclonal Antibody, Testing Data – Cat# MBS4380997

Other Notes

Small volumes of anti-IGHG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IGHG. It may not necessarily be applicable to this product.

NCBI GI #
121039
NCBI GeneID
3500
NCBI Accession #
P01857.1
UniProt Primary Accession #
P01857
UniProt Secondary Accession #
P01859; P01860; P01861
UniProt Related Accession #
P01857
NCBI Official Full Name
Immunoglobulin heavy constant gamma 1
NCBI Official Synonym Full Names
immunoglobulin heavy constant gamma 1 (G1m marker)
NCBI Official Symbol
IGHG1
UniProt Protein Name
Ig gamma-1 chain C region
Protein Family
Ig gamma-2A chain C region
UniProt Gene Name
IGHG1
UniProt Entry Name
IGHG1_HUMAN

UniProt Comments for IGHG

IGHG1: Defects in IGHG1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; antigen binding

Biological Process: innate immune response; complement activation, classical pathway; complement activation

Disease: Myeloma, Multiple
Show more

Research Articles on IGHG

1. Here, the authors demonstrate that SBP is actually the constant region of immunoglobulin G that binds to the membrane, specifically interacts with hepatitis B virus pre-Surface antigen (preS1) peptides, and enables HepG2 cells to uptake HBsAg preS1 peptides.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IGHG antibody

 Reference Product  PubMed Publications
 IGKC antibody  >1 publications with IGHG and IGKC

Pathways associated with anti-IGHG antibody

 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies  Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram

Organs/Tissues associated with anti-IGHG antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with IGHG and Blood
 Lymph Antibodies  >2 publications with IGHG and Lymph
 Lymph Node Antibodies  >2 publications with IGHG and Lymph Node
 Intestine Antibodies  >2 publications with IGHG and Intestine
 Skin Antibodies  >2 publications with IGHG and Skin
 Bone Antibodies  >1 publications with IGHG and Bone
 Bone Marrow Antibodies  >1 publications with IGHG and Bone Marrow
 Thyroid Antibodies  >1 publications with IGHG and Thyroid
 Pancreas Antibodies  >1 publications with IGHG and Pancreas
 Uterus Antibodies  >1 publications with IGHG and Uterus
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