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Langerin/CD207 (CD207) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4381141

MBS4381141 is an antibody targeting CD207. Also known as Langerin/CD207 (Marker of Langerhans Cells). Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Langerin/CD207, Monoclonal Antibody
Full Product Name
Langerin/CD207 (Marker of Langerhans Cells)
Product Gene Name
anti-CD207 antibody
Product Synonym Names
C-type lectin domain family 4 member K; CD207; CLEC4K; Langerhans cell specific c type lectin; Langerin
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
LGRN/1821
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Specificity
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
48kDa
OMIM
604862
3D Structure
ModBase 3D Structure for Q9UJ71
Positive Control
HeLa or A549 cells (WB).
Immunogen
Recombinant fragment (around aa74-213) of human Langerin protein (exact sequence is proprietary)
Cellular Localization
Cell Surface and Cytoplasmic
Hu-chromosome Location
2p13.3
Applications Tested/Suitable for anti-CD207 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CD207 antibody
ELISA: Use Ab at 2-4ug/ml for coating (Order Ab without BSA)
WB: 1-2ug/ml

SDS-Page of anti-CD207 antibody

SDS-PAGE Analysis Purified Langerin Mouse Monoclonal Antibody (LGRN/1821). Confirmation of Integrity and Purity of Antibody.
Mouse Anti-CD207 Monoclonal Antibody – Cat# MBS4381141

Testing Data of anti-CD207 antibody

Analysis of Protein Array containing more than 19,000 full-length human proteins using Langerin (CD207) Mouse Monoclonal Antibody (LGRN/1821). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.
Mouse Anti-CD207 Monoclonal Antibody, Testing Data – Cat# MBS4381141

Product References and Citations for anti-CD207 antibody

Valladeau, J., et al. 2000. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12: 71-81

Other Notes

Small volumes of anti-CD207 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD207. It may not necessarily be applicable to this product.

NCBI GI #
557357745
NCBI GeneID
50489
NCBI Accession #
NP_056532.4
UniProt Primary Accession #
Q9UJ71
UniProt Related Accession #
Q9UJ71
GenBank Nucleotide #
NP_056532.4
NCBI Official Full Name
C-type lectin domain family 4 member K
NCBI Official Synonym Full Names
CD207 molecule
NCBI Official Symbol
CD207
NCBI Official Synonym Symbols
CLEC4K
UniProt Protein Name
C-type lectin domain family 4 member K
UniProt Synonym Protein Names
Langerin; CD_antigen: CD207
Protein Family
C-type lectin domain family
UniProt Gene Name
CD207
UniProt Synonym Gene Names
CLEC4K
UniProt Entry Name
CLC4K_HUMAN
NCBI Protein Information
C-type lectin domain family 4 member K

NCBI Summary for CD207

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
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UniProt Comments for CD207

langerin: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. Homotrimer. Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: early endosome membrane; endocytic vesicle; plasma membrane

Molecular Function: carbohydrate binding; mannose binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; defense response to virus; receptor-mediated endocytosis

Disease: Birbeck Granule Deficiency
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Research Articles on CD207

1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD207 antibody

 Reference Product  PubMed Publications
 CD83 antibody  >22 publications with CD207 and CD83
 CD1C antibody  >19 publications with CD207 and CD1C
 CLEC9A antibody  >4 publications with CD207 and CLEC9A
 LAMP3 antibody  >1 publications with CD207 and LAMP3
 ITGAX antibody  >1 publications with CD207 and ITGAX

Pathways associated with anti-CD207 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway antibodies  Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-CD207 antibody

 Disease Name  Pubmed Publications
 Histiocytosis Antibodies  >45 publications with CD207 and Histiocytosis
 Inflammation Antibodies  >43 publications with CD207 and Inflammation
 Hypersensitivity Antibodies  >33 publications with CD207 and Hypersensitivity
 Necrosis Antibodies  >21 publications with CD207 and Necrosis
 Dermatitis, Contact Antibodies  >19 publications with CD207 and Dermatitis, Contact
 Disease Models, Animal Antibodies  >16 publications with CD207 and Disease Models, Animal
 Carcinoma in Situ Antibodies  >5 publications with CD207 and Carcinoma in Situ
 Kidney Diseases Antibodies  >5 publications with CD207 and Kidney Diseases
 Vascular Diseases Antibodies  >4 publications with CD207 and Vascular Diseases
 Respiratory Hypersensitivity Antibodies  >3 publications with CD207 and Respiratory Hypersensitivity

Organs/Tissues associated with anti-CD207 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >188 publications with CD207 and Skin
 Lung Antibodies  >23 publications with CD207 and Lung
 Brain Antibodies  >4 publications with CD207 and Brain
 Thyroid Antibodies  >2 publications with CD207 and Thyroid
 Uncharacterized Tissue Antibodies  >2 publications with CD207 and Uncharacterized Tissue
 Esophagus Antibodies  >1 publications with CD207 and Esophagus
 Bladder Antibodies  >1 publications with CD207 and Bladder
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