Mouse Anti-TAL1 Monoclonal Antibody – Cat# MBS4381279

SDS-PAGE Analysis Purified Tal1 Mouse Monoclonal Antibody (BTL73). Confirmation of Integrity and Purity of Antibody.

TAL1 Antibody – Mouse Monoclonal

Name: TAL1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS4381279
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4381279

MBS4381279 is an antibody targeting TAL1. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tal1, Monoclonal Antibody

Full Product Name

Tal1

Product Gene Name

anti-TAL1 antibody

Product Synonym Names

bHLHa17; Class A basic helix-loop-helix protein 17; OTTHUMP00000009563; OTTHUMP00000009564; SCL; STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; Tal 1 product; TAL 1 protein; TAL bHLH transcription factor 1 erythroid differentiation factor; TAL-1

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

BTL73

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Specificity

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.

Preparation and Storage

Store at -20°C. Non-Hazardous. No MSDS required.

OMIM

187040

3D Structure

ModBase 3D Structure for P17542

Positive Control

A549 xenograft.

Immunogen

Recombinant human full-length TAL1 protein

Cellular Localization

Nucleus

Research Area

Cardiovascular, Developmental Biology, Nuclear Marker, Transcription Factors

Applications Tested/Suitable for anti-TAL1 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-TAL1 antibody

ELISA: (For coating, order antibody without BSA)
WB: 1-2ug/ml
Optimal dilution for a specific application should be determined.

Product References and Citations for anti-TAL1 antibody

Chetty, R., et al. 1996. J. Pathol. 178: 311-315.

Other Notes

Small volumes of anti-TAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TAL1. It may not necessarily be applicable to this product.

NCBI GI #

4507363

NCBI GeneID

6886

NCBI Accession #

NP_003180.1

UniProt Primary Accession #

P17542

UniProt Related Accession #

P17542

GenBank Nucleotide #

NP_003180.1

NCBI Official Full Name

T-cell acute lymphocytic leukemia protein 1 isoform 1

NCBI Official Synonym Full Names

TAL bHLH transcription factor 1, erythroid differentiation factor

NCBI Official Symbol

TAL1

NCBI Official Synonym Symbols

SCL; TCL5; tal-1; bHLHa17

UniProt Protein Name

T-cell acute lymphocytic leukemia protein 1

UniProt Synonym Protein Names

Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5

Protein Family

Probable transaldolase

UniProt Gene Name

TAL1

UniProt Synonym Gene Names

BHLHA17; SCL; TCL5; TAL-1; bHLHa17

UniProt Entry Name

TAL1_HUMAN

NCBI Protein Information

T-cell acute lymphocytic leukemia protein 1

UniProt Comments for TAL1

TAL1: a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: transcription factor complex; histone deacetylase complex; nuclear chromatin; nucleus

Molecular Function: protein binding; enzyme binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; erythrocyte maturation; cell fate commitment; positive regulation of chromatin assembly or disassembly; embryonic hemopoiesis; megakaryocyte differentiation; positive regulation of transcription, DNA-dependent; positive regulation of erythrocyte differentiation; astrocyte fate commitment; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of protein complex assembly; positive regulation of cell division; erythrocyte differentiation; spinal cord association neuron differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; platelet formation; basophil differentiation

Disease: Leukemia, Acute Lymphoblastic

Research Articles on TAL1

1. Which was expressed in normal thymocytes but repressed in TAL1-positive T-ALL cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TAL1 antibody

Reference Product	PubMed Publications
LMO2 antibody	>104 publications with TAL1 and LMO2
LMO1 antibody	>25 publications with TAL1 and LMO1
TCF3 antibody	>16 publications with TAL1 and TCF3
GATA3 antibody	>15 publications with TAL1 and GATA3
SP1 antibody	>9 publications with TAL1 and SP1
EP300 antibody	>4 publications with TAL1 and EP300
MAPK3 antibody	>3 publications with TAL1 and MAPK3
HDAC1 antibody	>3 publications with TAL1 and HDAC1
SIN3A antibody	>2 publications with TAL1 and SIN3A

Diseases associated with anti-TAL1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>271 publications with TAL1 and Neoplasms
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Antibodies	>65 publications with TAL1 and Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Anemia Antibodies	>15 publications with TAL1 and Anemia
Disease Models, Animal Antibodies	>14 publications with TAL1 and Disease Models, Animal
Liver Diseases Antibodies	>2 publications with TAL1 and Liver Diseases
Vascular Diseases Antibodies	>2 publications with TAL1 and Vascular Diseases
Pain Antibodies	>1 publications with TAL1 and Pain
Skin Neoplasms Antibodies	>1 publications with TAL1 and Skin Neoplasms
Necrosis Antibodies	>1 publications with TAL1 and Necrosis
Hypertrophy Antibodies	>1 publications with TAL1 and Hypertrophy

Organs/Tissues associated with anti-TAL1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>274 publications with TAL1 and Blood
Bone Marrow Antibodies	>81 publications with TAL1 and Bone Marrow
Liver Antibodies	>40 publications with TAL1 and Liver
Brain Antibodies	>19 publications with TAL1 and Brain
Spleen Antibodies	>15 publications with TAL1 and Spleen
Heart Antibodies	>12 publications with TAL1 and Heart
Lung Antibodies	>4 publications with TAL1 and Lung
Placenta Antibodies	>2 publications with TAL1 and Placenta
Eye Antibodies	>1 publications with TAL1 and Eye