• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CD5 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438147

MBS438147 is an antibody targeting CD5. Also known as CD5 (Mantle Cell Lymphoma Marker) Mouse Monoclonal Antibody. Reactive in Human, Rabbit, Cow, Rat. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD5, Monoclonal Antibody
Full Product Name
CD5 (Mantle Cell Lymphoma Marker) Mouse Monoclonal Antibody
Product Gene Name
anti-CD5 antibody
Product Synonym Names
CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5
Clonality
Monoclonal
Isotype
IgG
Clone Number
C5/473 + CD5/54/F6
Host
Mouse
Species Reactivity
Human, Rabbit, Cow, Rat
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a mature T-cell neoplasms. Anti-CD5 detection is in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
67kDa
OMIM
153340
3D Structure
ModBase 3D Structure for P06127
Cellular Localization
Cell Surface
Immunogen
Human CD5 recombinant protein (C5/473); A synthetic peptide from the intracellular region of human CD5 (CD5/54/F6)
Hu-Chromosome Location
11q12.2
Positive Control
293T, Ramos, or MOLT-4 Cells. Tonsil.
Applications Tested/Suitable for anti-CD5 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-CD5 antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-CD5 antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with CD5 Monoclonal Antibody (C5/473 + CD5/54/F6)
Mouse Anti-CD5 Monoclonal Antibody – Cat# MBS438147

Product References and Citations for anti-CD5 antibody

Ferry JA et. al. American Journal of Clinical Pathology, 1996, 105(1):31-7. Gagneten D et. al. Diagnostic Cytopathology, 1996, 14(1):32-7

Other Notes

Small volumes of anti-CD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD5. It may not necessarily be applicable to this product.

NCBI GI #
166197668
NCBI GeneID
921
NCBI Accession #
NP_055022.2
UniProt Primary Accession #
P06127
UniProt Secondary Accession #
A0N0P4; A8K9I3
UniProt Related Accession #
P06127
GenBank Nucleotide #
NM_014207.3
NCBI Official Full Name
T-cell surface glycoprotein CD5
NCBI Official Synonym Full Names
CD5 molecule
NCBI Official Symbol
CD5
NCBI Official Synonym Symbols
T1; LEU1
UniProt Protein Name
T-cell surface glycoprotein CD5
UniProt Synonym Protein Names
Lymphocyte antigen T1/Leu-1; CD_antigen: CD5
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD5
UniProt Synonym Gene Names
LEU1
UniProt Entry Name
CD5_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD5

UniProt Comments for CD5

CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: plasma membrane

Molecular Function: protein binding
Show more

Research Articles on CD5

1. 5.2 % were positive for CD5 and 5.7 % positive for epstein-Barr virus encoded RNA

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD5 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >1735 publications with CD5 and CD4
 CD19 antibody  >1158 publications with CD5 and CD19
 CD2 antibody  >768 publications with CD5 and CD2
 CD7 antibody  >651 publications with CD5 and CD7
 CD79A antibody  >188 publications with CD5 and CD79A
 CD79B antibody  >117 publications with CD5 and CD79B
 CD72 antibody  >54 publications with CD5 and CD72
 LCK antibody  >32 publications with CD5 and LCK
 CD8A antibody  >7 publications with CD5 and CD8A

Pathways associated with anti-CD5 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD5 antibody

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >2021 publications with CD5 and Lymphoma
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >1030 publications with CD5 and Leukemia, Lymphocytic, Chronic, B-Cell
 Inflammation Antibodies  >189 publications with CD5 and Inflammation
 Necrosis Antibodies  >182 publications with CD5 and Necrosis
 Arthritis, Rheumatoid Antibodies  >180 publications with CD5 and Arthritis, Rheumatoid
 Anemia Antibodies  >155 publications with CD5 and Anemia
 Hyperplasia Antibodies  >102 publications with CD5 and Hyperplasia
 Lung Diseases Antibodies  >101 publications with CD5 and Lung Diseases
 Kidney Diseases Antibodies  >84 publications with CD5 and Kidney Diseases
 Lung Neoplasms Antibodies  >67 publications with CD5 and Lung Neoplasms

Organs/Tissues associated with anti-CD5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4344 publications with CD5 and Blood
 Spleen Antibodies  >682 publications with CD5 and Spleen
 Thymus Antibodies  >495 publications with CD5 and Thymus
 Brain Antibodies  >86 publications with CD5 and Brain
 Muscle Antibodies  >81 publications with CD5 and Muscle
 Heart Antibodies  >62 publications with CD5 and Heart
 Eye Antibodies  >47 publications with CD5 and Eye
 Connective Tissue Antibodies  >42 publications with CD5 and Connective Tissue
 Pancreas Antibodies  >32 publications with CD5 and Pancreas
 Uterus Antibodies  >27 publications with CD5 and Uterus
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000