Mouse Anti-TOM1L1 Monoclonal Antibody – Cat# MBS4381724

IHC analysis of formalin-fixed, paraffin-embedded human kidney. TOM1L1/4690 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9. 0, 45min. 2 degree : HRP-polymer, 30min. DAB, 5min.

Mouse Anti-TOM1L1 Monoclonal Antibody, Immunohistochemistry (IHC)-Formalin – Cat# MBS4381724

TOM1L1 Antibody – Mouse Monoclonal

Name: TOM1L1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS4381724
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4381724

Tom1 (target of Myb 1) is a 492 amino acid cytoplasmic protein that belongs to the Tom1 family. Widely expressed with highest expression in heart, liver, placenta and skeletal muscle, Tom1 is thought to be involved in intracellular trafficking and may be… More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TOM1L1 (Target of Myb1 Like 1 Membrane Trafficking Protein), Monoclonal Antibody

Full Product Name

TOM1L1 (Target of Myb1 Like 1 Membrane Trafficking Protein) Mouse Monoclonal Antibody [Clone TOM1L1/4690]

Product Gene Name

anti-TOM1L1 antibody

Product Synonym Names

2310045L10Rik; C80573; OK/KNS CL. 3; Src activating and signaling molecule; SRCASM; Target of Myb like protein 1; Target of myb1 (chicken) homolog like 1; Target of myb1 (chicken) like 1; TOM1 like protein 1; TOM1L1 protein

Clonality

Monoclonal

Isotype

Mouse/IgG

Clone Number

TOM1L1/4690

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration

Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (lot specific)

Preparation and Storage

Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

38,713 Da

OMIM

604701

3D Structure

ModBase 3D Structure for O75674

Immunogen

Recombinant full-length human TOM1L1 protein

Cellular Localization

Golgi apparatus > Golgi stack, Endosome membrane

Positive Control

Human kidney.

Hu-chromosome Location

17q22

Unigene

153504

Applications Tested/Suitable for anti-TOM1L1 antibody

Immunohistochemistry-Formalin (IHC-F)

Application Notes for anti-TOM1L1 antibody

IHC (Formalin-fixed): 1-2ug/ml for 30 minutes at RT
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH9.0, for 45 minutes at 95 degree C followed by cooling at RT for 20 minutes)

Other Notes

Small volumes of anti-TOM1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TOM1L1 purchase

MBS4381724 is an antibody targeting TOM1L1. Also known as TOM1L1 (Target of Myb1 Like 1 Membrane Trafficking Protein) Mouse Monoclonal Antibody [Clone TOM1L1/4690]. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TOM1L1. It may not necessarily be applicable to this product.

NCBI GI #

191252812

NCBI GeneID

10040

NCBI Accession #

NP_005477.2

UniProt Primary Accession #

O75674

UniProt Secondary Accession #

Q53G06; Q8N749

UniProt Related Accession #

O75674

GenBank Nucleotide #

NM_005486.2

NCBI Official Full Name

TOM1-like protein 1

NCBI Official Synonym Full Names

target of myb1 (chicken)-like 1

NCBI Official Symbol

TOM1L1

NCBI Official Synonym Symbols

SRCASM; OK/KNS-CL.3

UniProt Protein Name

TOM1-like protein 1

UniProt Synonym Protein Names

Src-activating and signaling molecule protein; Target of Myb-like protein 1

Protein Family

TOM1-like protein

UniProt Gene Name

TOM1L1

UniProt Synonym Gene Names

SRCASM

UniProt Entry Name

TM1L1_HUMAN

NCBI Protein Information

TOM1-like protein 1; target of myb1-like 1; target of myb 1-like 1; target of Myb-like protein 1; Src activating and signaling molecule; src-activating and signaling molecule protein

UniProt Comments for TOM1L1

Srcasm: an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosis of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: Golgi stack; lysosome; cytoplasm; endosome membrane; cytosol; endosome

Molecular Function: clathrin binding; protein binding; ubiquitin binding; SH3 domain binding; protein kinase activator activity; protein kinase binding

Biological Process: intracellular protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; negative regulation of mitosis; activation of protein kinase activity; signal transduction; positive regulation of protein amino acid autophosphorylation

Research Articles on TOM1L1

1. whereas TOM1L1 depletion only slightly affected SRC-induced proliferation of colorectal cancer cells in vitro, it drastically decreased tumor growth in xenografted nude mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TOM1L1 antibody

Reference Product	PubMed Publications
FYN antibody	>7 publications with TOM1L1 and FYN
GRB2 antibody	>4 publications with TOM1L1 and GRB2
EGFR antibody	>2 publications with TOM1L1 and EGFR
TSG101 antibody	>2 publications with TOM1L1 and TSG101
TOLLIP antibody	>2 publications with TOM1L1 and TOLLIP
LYN antibody	>1 publications with TOM1L1 and LYN

Organs/Tissues associated with anti-TOM1L1 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>4 publications with TOM1L1 and Skin
Brain Antibodies	>3 publications with TOM1L1 and Brain
Ear Antibodies	>1 publications with TOM1L1 and Ear
Thymus Antibodies	>1 publications with TOM1L1 and Thymus
Ovary Antibodies	>1 publications with TOM1L1 and Ovary
Kidney Antibodies	>1 publications with TOM1L1 and Kidney
Spleen Antibodies	>1 publications with TOM1L1 and Spleen
Testis Antibodies	>1 publications with TOM1L1 and Testis