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Interferon Regulatory Factor 9/IRF-9 (IRF9) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4381743

Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The… More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interferon regulatory factor 9/IRF-9 (IRF9), Monoclonal Antibody
Full Product Name
Interferon regulatory factor 9/IRF-9 Mouse Monoclonal Antibody [Clone PCRP-IRF9-2F8]
Product Gene Name
anti-IRF9 antibody
Product Synonym Names
IFN alpha responsive transcription factor subunit; Interferon regulatory factor 9; Interferon-stimulated gene factor 3 gamma; interferon-stimulated transcription factor 3, gamma 48kDa; IRF-9; ISGF-3 gamma; ISGF3 p48 subunit; ISGF3G; p48; Transcriptional regulator ISGF3 subunit gamma
Clonality
Monoclonal
Isotype
Mouse/IgG2a
Clone Number
PCRP-IRF9-2F8
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (lot specific)
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
393
OMIM
147574
3D Structure
ModBase 3D Structure for Q00978
Immunogen
Recombinant full-length human IRF9 protein
Cellular Localization
Cytoplasm, Nucleus, Translocated into the nucleus upon activation by IFN-alpha/beta
Positive Control
MCF-7, Jurkat or K562 cells.
Hu-chromosome Location
14q12
Unigene
1706
Applications Tested/Suitable for anti-IRF9 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-IRF9 antibody
FC/FACS: 1-2ug/million cells
IF: 1-2ug/ml

SDS-Page of anti-IRF9 antibody

SDS-PAGE Analysis. Purified IRF9 Mouse Monoclonal Antibody (PCRP-IRF9-2F8). Confirmation of Purity and Integrity of Antibody.
Mouse Anti-IRF9 Monoclonal Antibody – Cat# MBS4381743

Flow Cytometry (FC/FACS) of anti-IRF9 antibody

Mouse Anti-IRF9 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS4381743

Other Notes

Small volumes of anti-IRF9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF9 purchase

MBS4381743 is an antibody targeting IRF9. Also known as Interferon regulatory factor 9/IRF-9 Mouse Monoclonal Antibody [Clone PCRP-IRF9-2F8]. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF9. It may not necessarily be applicable to this product.

NCBI GI #
266392
NCBI GeneID
10379
NCBI Accession #
Q00978.1
UniProt Primary Accession #
Q00978
UniProt Secondary Accession #
D3DS61
UniProt Related Accession #
Q00978
NCBI Official Full Name
Interferon regulatory factor 9
NCBI Official Synonym Full Names
interferon regulatory factor 9
NCBI Official Symbol
IRF9
NCBI Official Synonym Symbols
p48; IRF-9; ISGF3; ISGF3G
UniProt Protein Name
Interferon regulatory factor 9
UniProt Synonym Protein Names
IFN-alpha-responsive transcription factor subunit; ISGF3 p48 subunit; Interferon-stimulated gene factor 3 gamma; ISGF-3 gamma; Transcriptional regulator ISGF3 subunit gamma
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF9
UniProt Synonym Gene Names
ISGF3G; IRF-9; ISGF-3 gamma
UniProt Entry Name
IRF9_HUMAN
NCBI Protein Information
interferon regulatory factor 9; ISGF-3 gamma; ISGF3 p48 subunit; interferon-stimulated gene factor 3 gamma; transcriptional regulator ISGF3 subunit gamma; IFN-alpha-responsive transcription factor subunit; interferon-stimulated transcription factor 3, gam

UniProt Comments for IRF9

IRF9: Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Belongs to the IRF family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; interferon type I biosynthetic process; defense response to virus
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Research Articles on IRF9

1. IL6 is an inducer of IRF9 expression in prostate cancer and a sensitizer for the antiproliferative effects of IFNalpha2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRF9 antibody

 Reference Product  PubMed Publications
 STAT1 antibody  >168 publications with IRF9 and STAT1
 STAT2 antibody  >126 publications with IRF9 and STAT2
 IRF7 antibody  >30 publications with IRF9 and IRF7
 ISG15 antibody  >12 publications with IRF9 and ISG15
 MX1 antibody  >7 publications with IRF9 and MX1
 IFIT3 antibody  >6 publications with IRF9 and IFIT3
 IFIT2 antibody  >4 publications with IRF9 and IFIT2
 IFIT1 antibody  >3 publications with IRF9 and IFIT1
 IFI6 antibody  >2 publications with IRF9 and IFI6

Pathways associated with anti-IRF9 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram

Diseases associated with anti-IRF9 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >19 publications with IRF9 and Inflammation
 Liver Diseases Antibodies  >16 publications with IRF9 and Liver Diseases
 Necrosis Antibodies  >14 publications with IRF9 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >8 publications with IRF9 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >7 publications with IRF9 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with IRF9 and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >5 publications with IRF9 and Brain Diseases
 Heart Diseases Antibodies  >3 publications with IRF9 and Heart Diseases
 Fibrosis Antibodies  >3 publications with IRF9 and Fibrosis
 Atherosclerosis Antibodies  >3 publications with IRF9 and Atherosclerosis

Organs/Tissues associated with anti-IRF9 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with IRF9 and Blood
 Liver Antibodies  >20 publications with IRF9 and Liver
 Lung Antibodies  >7 publications with IRF9 and Lung
 Skin Antibodies  >7 publications with IRF9 and Skin
 Brain Antibodies  >7 publications with IRF9 and Brain
 Vascular Antibodies  >6 publications with IRF9 and Vascular
 Muscle Antibodies  >5 publications with IRF9 and Muscle
 Kidney Antibodies  >5 publications with IRF9 and Kidney
 Bone Antibodies  >3 publications with IRF9 and Bone
 Heart Antibodies  >3 publications with IRF9 and Heart
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