Mouse Anti-FST Monoclonal Antibody – Cat# MBS4381749

SDS-PAGE Analysis Purified Follistatin Mouse Monoclonal Antibody (FST/4282). Confirmation of Purity and Integrity of Antibody.

Follistatin/Activin Binding Protein (FST) Antibody – Mouse Monoclonal

Name: FST Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS4381749
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4381749

Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin… More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Follistatin/Activin Binding Protein (FST), Monoclonal Antibody

Full Product Name

Follistatin/Activin Binding Protein Mouse Monoclonal Antibody [Clone FST/4282]

Product Gene Name

anti-FST antibody

Product Synonym Names

Follistatin, FS, FST, Active-binding protein

Clonality

Monoclonal

Isotype

Mouse/IgG1

Clone Number

FST/4282

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration

Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (lot specific)

Preparation and Storage

Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

38,007 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (52776264..52782304). Location: 5q11.2

OMIM

136470

3D Structure

ModBase 3D Structure for P19883

Immunogen

Recognizes human Follistatin isoform FS288, raised against recombinant human FS288.

Cellular Localization

Secreted

Positive Control

Human testis or ovary.

Hu-chromosome Location

5q11.2

Unigene

9914

Applications Tested/Suitable for anti-FST antibody

ELISA (EIA), Immunocytochemistry (ICC), Western Blot (WB)

Application Notes for anti-FST antibody

ELISA: 1ug/ml
ICC: 70ug/ml
WB: 1-2ug/ml

Other Notes

Small volumes of anti-FST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FST purchase

MBS4381749 is an antibody targeting FST. Also known as Follistatin/Activin Binding Protein Mouse Monoclonal Antibody [Clone FST/4282]. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FST. It may not necessarily be applicable to this product.

NCBI GI #

5453652

NCBI GeneID

10468

NCBI Accession #

NP_006341.1

UniProt Primary Accession #

P19883

UniProt Secondary Accession #

Q9BTH0; B5BU94

UniProt Related Accession #

P19883

GenBank Nucleotide #

NM_006350.3

NCBI Official Full Name

follistatin isoform FST317

NCBI Official Synonym Full Names

follistatin

NCBI Official Symbol

FST

NCBI Official Synonym Symbols

UniProt Protein Name

Follistatin

UniProt Synonym Protein Names

Activin-binding protein

Protein Family

Follistatin

UniProt Gene Name

FST

UniProt Synonym Gene Names

UniProt Entry Name

FST_HUMAN

NCBI Protein Information

follistatin; activin-binding protein; follistatin isoform FST317

NCBI Summary for FST

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

UniProt Comments for FST

FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function: heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding

Biological Process: hair follicle morphogenesis; negative regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; pattern specification process; odontogenesis of dentine-containing teeth; BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; gamete generation; hemopoietic progenitor cell differentiation; skeletal development; female gonad development

Disease: Polycystic Ovary Syndrome 1

Research Articles on FST

1. Serum measurements of activin A, B, or follistatin cannot discriminate risk for type 2 diabetes in individual patients, but the activins display a positive relationship with clinical parameters of the disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FST antibody

Reference Product	PubMed Publications
INHBA antibody	>9 publications with FST and INHBA
INHA antibody	>3 publications with FST and INHA
BMP5 antibody	>2 publications with FST and BMP5
FN1 antibody	>1 publications with FST and FN1

Pathways associated with anti-FST antibody

Products by Pathway	Pathway Diagram
Antagonism Of Activin By Follistatin Pathway antibodies	Antagonism Of Activin By Follistatin Pathway Diagram
BMP Receptor Signaling Pathway antibodies	BMP Receptor Signaling Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Activin Pathway antibodies	Signaling By Activin Pathway Diagram
TGF Beta Signaling Pathway antibodies	TGF Beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram

Diseases associated with anti-FST antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>45 publications with FST and Neoplasms
Brain Diseases Antibodies	>42 publications with FST and Brain Diseases
Learning Disorders Antibodies	>36 publications with FST and Learning Disorders
Drug Toxicity Antibodies	>34 publications with FST and Drug Toxicity
Cardiovascular Diseases Antibodies	>33 publications with FST and Cardiovascular Diseases
Inflammation Antibodies	>22 publications with FST and Inflammation
Cognition Disorders Antibodies	>17 publications with FST and Cognition Disorders
Necrosis Antibodies	>16 publications with FST and Necrosis
Memory Disorders Antibodies	>15 publications with FST and Memory Disorders
Insulin Resistance Antibodies	>13 publications with FST and Insulin Resistance

Organs/Tissues associated with anti-FST antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>586 publications with FST and Brain
Skin Antibodies	>63 publications with FST and Skin
Nerve Antibodies	>62 publications with FST and Nerve
Bone Antibodies	>41 publications with FST and Bone
Eye Antibodies	>36 publications with FST and Eye
Ovary Antibodies	>31 publications with FST and Ovary
Heart Antibodies	>25 publications with FST and Heart
Liver Antibodies	>24 publications with FST and Liver
Adrenal Gland Antibodies	>19 publications with FST and Adrenal Gland
Testis Antibodies	>18 publications with FST and Testis