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RBP4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4382183

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to… More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
RBP4/Retinol Binding Protein 4, Monoclonal Antibody
Full Product Name
RBP4/Retinol Binding Protein 4 Mouse Monoclonal Antibody [Clone RBP4/4049]
Product Gene Name
anti-RBP4 antibody
Product Synonym Names
Plasma retinol binding protein 4 (PRBP); RDCCAS; Retinol binding protein 4 interstitial
Clonality
Monoclonal
Isotype
Mouse/IgG1, kappa
Clone Number
RBP4/4049
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (lot specific)
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
23,010 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (95351593..95360993, complement). Location: 10q23-q24
OMIM
180250
3D Structure
ModBase 3D Structure for P02753
Immunogen
Recombinant fragment (around aa29-148) of human RBP4 protein (exact sequence is proprietary)
Cellular Localization
Secreted
Positive Control
HeP-G2 cells. Human kidney, pancreas or liver tissues.
Hu-chromosome Location
10q23.33
Unigene
50223
Applications Tested/Suitable for anti-RBP4 antibody
Immunohistochemistry-Formalin (IHC-F)
Application Notes for anti-RBP4 antibody
IHC (Formalin-fixed): 1-2ug/ml for 30 minutes at RT
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH9.0, for 45 minutes at 95 degree C followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC)-Formalin of anti-RBP4 antibody

Formalin-fixed, paraffin-embedded human kidney stained with RBP4 Mouse Monoclonal Antibody (RBP4/4049).
Mouse Anti-RBP4 Monoclonal Antibody – Cat# MBS4382183

Immunohistochemistry (IHC) of anti-RBP4 antibody

Mouse Anti-RBP4 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4382183

Other Notes

Small volumes of anti-RBP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RBP4 purchase

MBS4382183 is an antibody targeting RBP4. Also known as RBP4/Retinol Binding Protein 4 Mouse Monoclonal Antibody [Clone RBP4/4049]. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for RBP4. It may not necessarily be applicable to this product.

NCBI GI #
55743122
NCBI GeneID
5950
NCBI Accession #
NP_006735.2
UniProt Primary Accession #
P02753
UniProt Secondary Accession #
O43478; O43479; Q5VY24; Q8WWA3; Q9P178; D3DR38
UniProt Related Accession #
P02753
GenBank Nucleotide #
NM_006744.3
NCBI Official Full Name
retinol-binding protein 4
NCBI Official Synonym Full Names
retinol binding protein 4, plasma
NCBI Official Symbol
RBP4
NCBI Official Synonym Symbols
RDCCAS
UniProt Protein Name
Retinol-binding protein 4
UniProt Synonym Protein Names
Plasma retinol-binding protein
Protein Family
Retinol-binding protein
UniProt Gene Name
RBP4
UniProt Synonym Gene Names
PRBP; RBP
UniProt Entry Name
RET4_HUMAN
NCBI Protein Information
retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial

NCBI Summary for RBP4

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
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UniProt Comments for RBP4

RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: extracellular space; protein complex; extracellular region; cytosol

Molecular Function: protein binding; protein heterodimerization activity; retinol binding; retinal binding

Biological Process: phototransduction, visible light; retinal metabolic process; heart development; embryonic skeletal development; maintenance of gastrointestinal epithelium; glucose homeostasis; uterus development; response to insulin stimulus; embryonic organ morphogenesis; negative regulation of cardiac muscle cell proliferation; retinol metabolic process; detection of light stimulus involved in visual perception; retinoid metabolic process; female genitalia morphogenesis; cardiac muscle development; response to retinoic acid; urinary bladder development; male gonad development; vagina development; positive regulation of insulin secretion; positive regulation of immunoglobulin secretion; gluconeogenesis; response to ethanol; eye development; embryonic retina morphogenesis in camera-type eye; spermatogenesis; lung development

Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10
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Research Articles on RBP4

1. In a cohort of women, higher circulating full-length and total RBP4 levels are associated with increased risk of coronary heart disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RBP4 antibody

 Reference Product  PubMed Publications
 TTR antibody  >28 publications with RBP4 and TTR
 STRA6 antibody  >14 publications with RBP4 and STRA6
 AHSG antibody  >4 publications with RBP4 and AHSG
 AMBP antibody  >2 publications with RBP4 and AMBP
 ALB antibody  >2 publications with RBP4 and ALB
 CYP2C9 antibody  >1 publications with RBP4 and CYP2C9
 PSMB1 antibody  >1 publications with RBP4 and PSMB1
 RPE65 antibody  >1 publications with RBP4 and RPE65

Pathways associated with anti-RBP4 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Retinoid Cycle Disease Events Pathway antibodies  Retinoid Cycle Disease Events Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
 Retinoate Biosynthesis I Pathway antibodies  Retinoate Biosynthesis I Pathway Diagram

Diseases associated with anti-RBP4 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >62 publications with RBP4 and Inflammation
 Cardiovascular Diseases Antibodies  >58 publications with RBP4 and Cardiovascular Diseases
 Liver Diseases Antibodies  >54 publications with RBP4 and Liver Diseases
 Fatty Liver Antibodies  >48 publications with RBP4 and Fatty Liver
 Necrosis Antibodies  >43 publications with RBP4 and Necrosis
 Hyperglycemia Antibodies  >38 publications with RBP4 and Hyperglycemia
 Kidney Diseases Antibodies  >29 publications with RBP4 and Kidney Diseases
 Glucose Intolerance Antibodies  >28 publications with RBP4 and Glucose Intolerance
 Neoplasms Antibodies  >28 publications with RBP4 and Neoplasms
 Polycystic Ovary Syndrome Antibodies  >22 publications with RBP4 and Polycystic Ovary Syndrome

Organs/Tissues associated with anti-RBP4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >118 publications with RBP4 and Liver
 Connective Tissue Antibodies  >89 publications with RBP4 and Connective Tissue
 Muscle Antibodies  >46 publications with RBP4 and Muscle
 Kidney Antibodies  >26 publications with RBP4 and Kidney
 Heart Antibodies  >24 publications with RBP4 and Heart
 Bone Antibodies  >14 publications with RBP4 and Bone
 Brain Antibodies  >12 publications with RBP4 and Brain
 Pancreas Antibodies  >10 publications with RBP4 and Pancreas
 Embryonic Tissue Antibodies  >9 publications with RBP4 and Embryonic Tissue
 Lung Antibodies  >8 publications with RBP4 and Lung
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